A prospective, split-face, randomized, open-label study comparing efficacy of trichloroacetic acid (100%) and cryotherapy in xanthelasma palpebrarum

Moizza Tahir, Javeria Hafeez, Muhammad Irfan Anwar, Uzma Bashir, Nasser Rashid Dar


Objective To compare the clinical efficacy of trichloroacetic acid (TCA) 100% and cryotherapy in xanthelasma palpebrarum (XP).


Methods 40 patients fulfilling the inclusion criteria were treated with cryotherapy on right eye (group A) and TCA on left eye (group B). Patients were followed up for 6 weeks and final outcome variable of efficacy i.e. complete resolution of xanthelasma was assessed at 6 weeks. Adverse side effects of therapy were also recorded as secondary outcome variables.  Data were analyzed by SPSS 19.0.


Results Mean age of patients was 43.75 ± 5.90 years and age ranged from 34 to 56 years. Out of 40 patients 9 (22.5%) were male and 40 (77.5%) were female. Complete resolution of xanthelasma was seen in only 7 (17.5%) in group A, while complete resolution of lesions was seen in 30 (75%) of patients in group B (p = 0.000).


Conclusion A single session of 100% TCA is highly effective than cryotherapy in the treatment of Xanthelasma palpebrarum .



Xanthelasma, xanthomatosis, trichloroacetic acid, cryotherapy

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