A comparison of the efficacy of topical adapalene gel 0.1% with tretinoin gel 0.025% in mild acne vulgaris

Mehran Khan, Naimat Ullah Khan, Muhammad Irfan Anwar, Sahibzada Mahmood Noor


Objective  To compare the efficacy of topical adapalene with topical tretinoin in the treatment of mild acne  vulgaris .


Methods  This randomized controlled trial was conducted over a period of 6 months in outpatient department of dermatology, Lady Reading Hospital, Peshawar. 101 patients were taken after nonprobability consecutive sampling in each group. Topical adapalene 0.1% gel was given to group A while topical tretinoin 0.025% gel was given to group B for once daily application. Efficacy was ascertained after the end of third month and was graded as excellent or poor response. The data were statistically analyzed using SPSS version 11.


Results  Out of 202 patients, male and female patients were 91 and 111, respectively with male to female ratio 0.8:1. The age of the patients ranged from 15-25 years. Mean age in group A was 19.79 ± 2.24  years while in group B, it was 20.11 ± 2.53  years. Overall efficacy in adapalene group was 84.2% as compared to 39.6% of tretinoin group (p=0.000).


Conclusion  Topical adapalene has a better efficacy than topical tretinoin in the treatment of mild acne vulgaris .



Acne, adapalene, tretinoin

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