Clinico-epidemiological study of alopecia areata

Arun Achar, Sanjay K Rathi, Leishiwon Kumrah, Rabindranath Biswas, Samiran Bisai

Abstract


Objective To evaluate the clinical and demographical pattern of alopecia areata (AA) and their association with other diseases.

 

Methods A cross-sectional multicentric study of 410 patients with AA was carried out during the period of January 2013 to December 2014. A detail clinical and demographical pattern of the disease was taken in a prescribed proforma along with the association of other diseases, if present.

 

Results A total of 410 patients with AA were included in the study with age ranging from 1 year to 74 years, out of which 206 were males and 204 females. The commonest age at onset was 21-30 years. Multilocular patches were the commonest presentation. Based on the pattern, patchy AA was most commonly seen, followed by ophiasis and sisiapho. Eyebrow involvement was common in the ophiasis group as compared to other types. Nail involvement was found in 45.4% patients and pitting was the most common finding. A history of previous episode of AA was present in 32.4% of patient. Severity of AA with increasing area of involvement was seen in the relapse group of patients. Scalp was the commonest hair bearing area of involvement (76.8%), as well as, was also the first site of involvement. In 12.7%, there was a past history of AA. The commonest associated disease was atopic dermatitis (5.8%). Other diseases like thyroid, vitiligo, diabetes, collagen-vascular disease etc. were also noted in our study.

 

Conclusion AA is a disease of the younger age group. We assessed the demographic profile of the patients and try to correlate it with other studies and hypothesis.

 


Keywords


Alopecia areata, clinical features, epidemiology

Full Text:

PDF

References


Sharma VK, Dawn G, Kumar B. Profile of alopecia areata in Northern India. Int J Dermatol. 1996;35:22-7.

Mirzoyev SA, Schrum AG, Davis MD, Torgerson RR. Lifetime incidence risk of alopecia areata estimated at 2.1% by Rochester Epidemiology Project, 1990-2009. J Invest Dermatol. 2014;134:1141-2.

Seetharam KA. Alopecia areata: An update. Indian J Dermatol Venereol Leprol. 2013;79:563-75.

Huang KP, Mullangi S, Guo Y, Qureshi AA. Autoimmune, atopic, and mental health comorbid conditions associated with alopecia areata in the United States. JAMA Dermatol. 2013;149:789-94.

Panda M, Jena M, Patro N, Dash M, Jena AK, Mishra S. Clinico-epidemiological profile and therapeutic response of alopecia areata in a tertiary care teaching hospital. J Pharm Sci Res. 2014;6:169-74.

Jain S, Marfatia YS. Alopecia areata: Pattern in industrial city of Baroda. Indian J Dermatol Venereol Leprol. 2003;69:81-2.

Shellow WV, Edwards JE, Koo JY. Profile of alopecia areata: a questionnaire analysis of patient and family. Int J Dermatol. 1992;31:186-9.

Anderson I. Alopecia areata: a clinical study. Br Med J. 1950;2:1250-2.

De Weert J, Temmerman L, Kint A. Alopecia areata: a clinical study. Dermatologica. 1984;168:224-9.

Seyrafi H, Akhiani M, Abbasi H, Mirpour S, Gholamrezanezhad. Evaluation of the profile of alopecia areata and the prevalence of thyroid function test abnormalities and serum autoantibodies in Iranian patients. BMC Dermatol. 2005;5:11 doi:10.1186/1471-5945-5-11.

Manzoor S, Masood C. AA in Kashmir: A study of 200 patients. Indian J Dermatol Venereol Leprol. 2001;67:324-5.

Kasumagic-Halilovic E, Prohic A. Nail changes in alopecia areata: frequency and clinical presentation. J Eur Acad Dermatol Venereol. 2009;23:240-1.

Gandhi V, Baruah MC, Bhattacharya SN. Nail changes in alopecia areata: incidence and pattern. Indian J Dermatol Venereol Leprol. 2003;69:114-5.

Muller HA, Winkelmann, RK. Alopecia areata: An evaluation of 736 patients. Arch Dermatol. 1963;88:290-7.

Sharma VK, Dawn G, Murlidhar S, Kumar B. Nail changes in 1000 Indian patients with alopecia areata. J Eur Acad Dermatol Venereol. 1998;10:189-91.

Spano F, Donovan JC. Alopecia areata: part 1: pathogenesis, diagnosis, and prognosis. Can Fam Physician. 2015;61:751-5.

De Waard-van der Spek FB, Oranje AP, De Raeymaecker DM, Peereboom-Wynia JD. Juvenile versus maturity-onset alopecia areata-a comparative retrospective clinical study. Clin Exp Dermatol. 1989;14:429-33.

Gip L, Lodin A, Molin L. Alopecia areata – A follow up investigation of out patient material. Acta Derm Venereol. 1969;49:180-8.

Alkhalifah A, Alsantali A, Wang E, McElwee KJ, Shapiro J. Alopecia areata update, part I: clinical picture, histopathology, and pathogenesis. J Am Acad Dermatol. 2010;62:177-88.

Kurtev A, Iliev E. Thyroid autoimmunity in children and adolescents with alopecia areata. Int J Dermatol. 2005;44:457-61.

Barahmani N, Schabath MB, Duvic M. History of atopy or autoimmunity increase risk of alopecia areata. J Am Acad Dermatol. 2009;61:581-91.

Tosti A, Bellavista S, Iorizzo M. Alopecia areata: a long term follow-up study of 191 patients. J Am Acad Dermatol. 2006;55:438-41.

Villasante Fricke AC, Miteva M. Epidemiology and burden of alopecia areata: a systemic review. Clin Cosmet Investig Dermatol. 2015;8:397-403


Refbacks

  • There are currently no refbacks.


ISSN: 1560-9014