Eccrine syringofibroadenoma: an unusual presentation of a rare disease

Arun Achar, Biswanath Naskar, Gobinda Chatterjee, Mallika Pal, Saugata Ray


Eccrine syringofibroadenoma (ESFA) is a rare disorder with differentiation towards ductal eccrine apparatus. There are a variety of clinical manifestations and distribution of lesions but the histopathological features are remarkably similar with benign appearing anastomosing cords of eccrine ductal epithelial cells with or without lumina formation, are embedded in loose fibrovascular stroma. We report a case of 55-year-old Muslim man having large pale pink slightly verrucous plaque on right upper back since last 20 years with central ulceration for 8 years. Punch biopsy was done and showed features of ESFA.



Eccrine syringofibroadenoma

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Mascaro JM. Considerations on fibro-epithelial tumors: exocrine syringofibroadenoma. [French]. Ann Dermatol Syph 1963; 90:143-53.

Mcniff J. Benign tumors with apocrine and eccrine differentiation. In: Leboit P, Weedon D, Sarason A, eds. World Health Organization Classification of Tumors: Pathology and Genetics, Skin Tumors. Lyon, France: IARC; 2006. p. 142.

Weedon D, ed. Skin Pathology. New York: Churchill Livingstone; 2002. P. 894-5.

Bjarke T, Ternesten-Bratel A, Hedblad M, Rausing A. Carcinoma and eccrine syringofibroadenoma: a report of five cases. J Cutan Pathol 2003; 30: 382-92.

Katane M, Akiyama M, Ohnishi T et al. Carcinomatous transformation of eccrine syringofibroadenoma. J Cutan Pathol 2003; 30: 211-4.

McKee P. Eccrine syringofibroadenoma. In: McKee P, Calonje E, Granter S, editors. Pathology of the Skin with Clinical Correlations. Philadelphia: Elsevier; 2005. p. 1612-3.

Hurt MA, Igra-Serfaty H, Stevens CS. Eccrine syringofibroadenoma (Mascaro); an acrosyringeal hamartoma. Arch Dermatol 1990; 126: 945-9.

Ohnishi T, Suzuki T, Watanabe S. Eccrine syringofibroadenoma: report of a case and immunohistochemical study of keratin expression. Br J Dermatol 1995; 133: 449-54.

Takeda H, Mitsuhashi Y, Yoshikawa K et al. Eccrine syringofibroadenoma: report of a case and analysis of cytokeratin expression. Dermatology 1998; 196: 242-5.

Ishida-Yamamoto A, Lizuka H. Eccrine syringofibroadenoma (Mascaro): an ultrastructural and immunohistochemical study. Am J Dermatopathol 1996; 18: 207-11.


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