Analysis of vitamin D receptor levels in serum of leprosy patients of multibacillary type, erythema nodosum leprosum and normal people
Keywords:
Erythema Nodosum Leprosum, Leprosy, Vitamin D ReceptorAbstract
Objective Erythema Nodosum Leprosum (ENL) is an acute inflammatory reaction that occurs only in multibacillary (MB) leprosy patients. Serum Vitamin D Receptor (VDR) has been widely used as a biomarker to determine the progress of therapy in various diseases. This study aims to determine the difference between serum VDR in MB type leprosy patients who experience ENL reactions and those who do not experience ENL reactions and healthy people. Methods The research was conducted using an analytic observational study with a cross sectional method. The total number of samples is 36 people, where each group consists of 12 people. Results Mean serum VDR of multibacillary leprosy patients with an ENL reaction was 10.41 (4.34±18.12), whereas in the group without ENL it was 25.92 (23.32±29.42) and in the healthy group it was 39.51 (34.54±42.67). Conclusion Based on statistical tests, it was found that serum VDR was significantly different between multibacillary leprosy patients who experienced ENL reactions and patients who did not experience ENL reactions and healthy people.References
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