Concurrent of Pemphigus Vulgaris and Pemphigus Foliaceus in the Same Patient : Rare Case
Abstract
Easily ruptured superficial vesicles or bullae are a hallmark of the chronic autoimmune illness pemphigus. The two primary subtypes of pemphigus are pemphigus vulgaris (PV) and pemphigus foliaceus (PF), which can infrequently coexist or even change from one to the other. Changes in the autoantibody profile for desmoglein that are both qualitative and quantitative may help to explain this process. We describe a case of PF and PV present at the same time on a 73-year-old woman from clinical findings revealed multiple flaccid bullae on the face, neck, left and right arm and thigh, stomach, and back. Erosions, excoriations, and crusts were present. Nikolsky's sign was positive. Her histopathological examination showed subcorneal and suprabasal acantholysis. Basal cells were formed in a “row of tombstones” appearance.References
Hasan S, Ahmed S, Kiran R. Pemphigus Vulgaris: An Update on Ethiopathogenesis, Clinical Manifes-tations, Diagnosis and Treatment Modalities. Int Res J Pharm. 2019; 10(3): 1-6.
Malik AM, Tupchong S, Huang S. An Up-dated Review of Pemphigus Diseases. Medicina. 2021; 57: 1-15.
Perks AC, Farthing PM, Murphy R. A Case of Concomitant Pemphigus Foliaceus and Oral Pem-phigus Vulgaris. Head and Neck Pathology. 2018; 12: 592-7.
Payne AS, Stanley JR. Vesiculobullous Disorders: Pemphigus. Dalam: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael A dan Orrin-ger JS, editor. Fitzpatrick’s Dermatology in General Medicine. Edisi 9. New York: Mc Graw Hill Inc. 2019; p. 909-33.
Porro AM, Filho GH, Santi CG. Consensus on the treatment of autoimmune bullous dermatoses: pemphigus vulgaris and pemphigus foliaceus – Brazilian Society of Dermatology. 2019; 94(2): 20-32.
Gregoriou S, Efthymiou O, Stefanaki C. Mana-gement of pemphigus vulgaris: challenges and sol-utions. Clinical, Cosmetic and Investigational Der-matology. 2015; 8: 521- 7.
Durmaz K, Dursun R, Ataseven A. Coexistence of pemphigus vulgaris and pemphigus foliaceus in the same patient at the same time. Dermatol Case Rep. 2017; 2(124): 1-2.
Murrell DF, Pena S, Joly P. Diagnosis and Management of Pemphigus: recommendations by an International Panel of Experts. Journal of the American Academy of Dermatology. 2018. 1-35.
Fernandes NC, Perez M. Treatment of Pemphigus Vulgaris and Pemphigus Foliaceus: Experience with 71 Patients Over A 20 Year Period. Rev Inst Med Trop. 2001; 43(1): 33-6
Saha M, Bhogai B, Black MM. Prognostic fac-tors in pemphigus vulgaris and pemphigus foli-aceus. British Journal of Dermatology. 2013; 170(1): 116-22.
