Urticaria as a Cutaneous Manifestation of SARS-CoV-2 Infection - A Case Report
Abstract
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus is responsible for causing the infection known as Coronavirus disease 2019 (COVID-19). Clinical manifestations of COVID-19 have been associated with various symptoms, but skin manifestations are rarely seen. A 25-year-old woman presented with complaints of erythematous urticarial plaques accompanied by itching over buttocks, waist, right arm, and right toe for one day, and confirmed positive for COVID-19. There is research on the timing of skin rash appearance in COVID-19 patients, with 46.1% of rashes appearing simultaneously with prodromal symptoms, 44.3% appearing after and 9.6% appearing before prodromal symptoms, with varying resolution time period.References
World Health Organization. Situation report, 3: Novel Coronavirus (2019-nCoV) outbreak. 2020 [cited 2025 Jun 24]. Available from:
https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200123-sitrep-3-2019-ncov.pdf?sfvrsn=d6d23643_8
Lu H, Stratton CW, Tang YW. Outbreak of pneu-monia of unknown etiology in Wuhan, China: the mystery and the miracle. J Med Virol. 2020;92(4): 401–2.
Dewi MR. Manifestasi Kulit pada Pasien COVID-19. Medula. 2020;10(3):437–42.
Gottlieb M, Long B. Dermatologic manifestations and complications of COVID-19. Am J Emerg Med. 2020;38(9):1715–21.
Recalcati S. Cutaneous manifestations in COVID?19: a first perspective. J Eur Acad Dermatol Vene-reol. 2020;34(5):e212–3.
Daneshgaran G, Dubin DP, Gould DJ. Cutaneous manifestations of COVID-19: an evidence-based review. Am J Clin Dermatol. 2020;21(5):627–39.
Fernandez?Nieto D, Jimenez?Cauhe J, Suarez?Valle A, Moreno?Arrones OM, Saceda?Corralo D, Arana?Raja A, et al. Comment on: Cutaneous manifestat-ions in COVID?19: a first perspective. Safety con-cerns of clinical images and skin biopsies. J Eur Acad Dermatol Venereol. 2020;34(6):e252–4.
Galvan Casas C, Catala A, Carretero Hernandez G, Rodriguez-Jimenez P, Fernandez-Nieto D, Rodri-guez-Villa Lario A, et al. Classification of the cuta-neous manifestations of COVID?19: a rapid pros-pective nationwide consensus study in Spain with 375 cases. Br J Dermatol. 2020;183(1):71–7.
Bourgonje AR, Abdulle AE, Timens W, Hillebrands JL, Navis GJ, Gordijn SJ, et al. Angiotensin?convert-ing enzyme 2 (ACE2), SARS?CoV?2 and the patho-physiology of coronavirus disease 2019 (COVID?19). J Pathol. 2020;251(3):228–48.
Cordoro KM, Reynolds SD, Wattier R, McCalmont TH. Clustered cases of acral perniosis: clinical fea-tures, histopathology, and relationship to COVID?19. Pediatr Dermatol. 2020;37(3):419–23.
Sanchez-Borges M, Asero R, Ansotegui IJ, Baiardini I, Bernstein JA, Canonica GW, et al. Diagnosis and treatment of urticaria and angioedema: a world-wide perspective. World Allergy Organ J. 2012; 5(11):125–47.
