Psoriasis and subclinical atherosclerosis: A significant association

Amlan Kanti Biswas, Sanchaita Bala, Sumit Sen, Anindya Bandyopadhyay, Samir Chakraborty, Supriyo Choudhury, Atul Jain, Banashree Majumdar, Gobinda Chatterjee


Objective: To identify the presence of subclinical therosclerosis by measuring carotid intima medial thickness (IMT) in patients with psoriasis attending the dermatology clinic of a tertiary care hospital.

Methods: 30 patients who fulfilled the exclusion and inclusion criteria were recruited. 5 healthy persons devoid of known cardiovascular risk factors were registered as controls. Intima medial thickness of common carotid and vertebral arteries of both sides were measured by B mode ultrasound.

Results: Result showed that IMT and velocity of left common carotid artery and velocity in right vertebral artery were significantly greater in psoriatic patients than control group and psoriatic patients had 0.8 times greater risk of developing  atherosclerosis than control group.

Conclusion: Subclinical atherosclerosis remains undiagnosed in patients of psoriasis who usually lack the established risk factors for cardiovascular disease.


Psoriasis, atherosclerosis, intima medial thickness


Alkaabi JK, Ho M, Levison R et al. Rheumatoid arthritis and macrovascular disease. Rheumatology (Oxford).2003;42:292-7.

Naldi L, Chatenoud L, Linder D et al. Cigarette smoking, body mass index and stressful life events as risk factors for psoriasis: results from Italian case control study. J Invest Dermatol. 2005;125:61-7.

Bartoli F, Blagojevic J, Bacci M et al. Flow mediated vasodilatation and carotid

intima-media thickness in systemic sclerosis. Ann N Y Acad Sci. 2007;1108:283-90.

Beyne-Rauzy O, Leger P, Godel A et al. Intima-media thickness evaluation in 45 systemic scleroses compared to healthy subjects matched for sex and gender. The Johns Hopkins Arthritis Center. Abstract 1678. 1998-2007.

Manzi S, Selzer F, Sutton-Tyrrell K et al. Prevalence and risk factors of carotid

plaque in women with systemic lupus erythematousus. Arthritis Rheum. 1999;42:51-60.

Ebrahim S, Papacosta O, Whincup P et al. Carotid plaque, intima media thickness,

cardiovascular risk factors, and prevalent cardiovascular disease in men and women: the British Regional Heart Study. Stroke. 1999;30:841-50.

Hodis HN, Mack WJ, LaBree L et al. The role of carotid arterial intima media thickness in predicting clinical coronary events. Ann Intern Med. 1998;128:262-9.

Ludwig RJ, Herzog C, Rostock A et al. Psoriasis: a possible risk factor for development of coronary artery calcification. Br J Dermatol. 2007;156:271-6.

Kimhi O, Caspi D, Bornstein NM, Maharshak N, Gur A, Arbel Y, et al. Prevalence and risk factors of athrosclerosis in patients with psoriatic arthritis. Semin Arthritis Rheum. 2007;36:203-9.

Gonzalez-Juanatey C, Llorca J, Amigo-Diaz E et al. High prevalence of subclinical atherosclerosis in psoriatic arthritis patients without clinically evident cardiovascular disease or classic atherosclerosis risk factors. Arthritis Rheum. 2007;57:1074-80.

Balci DD, Balci A, Karazincir S et al.Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis. J Eur Acad Dermatol Venereol. 2009;23:1-6.

El-Mongy S, Fathy H, Abdelaziz A et al. Subclinical atherosclerosis in patients with

chronic psoriasis: a potential association. J Eur Acad Dermatol Venereol. 2010.;24:661-6.


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