Comparison of the efficacy and safety of 40% glycolic acid & 60% lactic acid chemical peel in treatment of epidermal melasma

Asia Hafeez, Shehla Shaukat, Madiha Sanai, Tahir Jamil Ahmad, Shahbaz Aman

Abstract


Objective To compare the efficacy and safety of chemical peel with 40% glycolic acid and  60% lactic acid in the treatment of epidermal melasma.

 

Methods In this comparative interventional study, 112 patients of 18 to 40 years, suffering from epidermal melasma, not taking any treatment for melasma for last 4 weeks were included. Pre-treatment melasma area severity index (MASI) was calculated. 56 patients were treated with lactic acid peel and 56 with glycolic acid peel. Total of 6 sessions of each peel with 4 weeks interval were done and then monthly post treatment follow up for 2 months. During each visit MASI score was calculated. Photographs were taken at baseline and at follow-up visit.  Percentage reduction of MASI was calculated at the end of therapy.

 

Results In Group A, treated with 40% glycolic acid chemical peeling, efficacy of treatment was seen in 38 (67.5%), while in Group B, treated with 60% lactic acid chemical peeling efficacy was seen in 45 (80.4%). This proved that efficacy was higher in Group B but was not significantly different (P value=0.13) so final MASI reduced significantly in both study groups. Side effects e.g burning, erythema, scarring, crusting, post peel hypo/hyper pigmentation were 52 (64.20%) in Group A and 29 (35.80%) in Group B.

 

Conclusion Both 40% Glycolic acid & 60% lactic acid chemical peeling agents are effective in treatment of epidermal melasma. 60% Lactic acid chemical peel is safer than 40% Glycolic acid chemical peel.

 


Keywords


Epidermal Melasma, chemical peel, Glycolic acid, Lactic acid

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References


Sarkar R, Bansal S, Garg VK. Chemical peels for melasma in dark skinned patients. J Cutan and Asthet surg 2012; 5(4): 247-53.

Kodali S, Ian LG, Carrigan RC, Daulat S, Blanco G, Boker A et al. A prospective, randomized, split face, controlled trial of salicylic acid peels in treatment of melasma in latin american women. J Am Acad Dermatol 2009; 63(6): 1030-5.

Ethawi AMD, Sidiq LM. Comparison of the effect of salicylic acid chemical peel combined with topical modified kligman formula and topical modified kligman formula alone in the treatment of melasma. The Iraqi Postgrad Med J 2011; 10(2): 191-7.

Puri N. Comparative study of 15% TCA peel versus 35% glycolic acid peel for the treatment of melasma. Indian Dermatol Online J 2012; 3(2): 109- 13.

Gulzar K, Mujtaba G, Hameed S. Comparison between efficacy of serial glycolic acid peel and triple combination creams vs. triple combination cream alone in treatment of melasma. J Pak Dermatol 2010; 20: 84-8.

Rossi A, Perez MI. Cosmetic concern in melasma part 2 treatment options and approaches. Cosmet Dermatol 2011; 24(12): 575-8.

Kumari R, Thappa DM. Comparative study of trichloroacetic acid versus glycolic acid chemical peels in the treatment of melasma. Indian J Dermatol Venereol Leprol 2010; 76(4): 447.

Mashhadani SA, Shariquie KE, Tikreety MM. Lactic acid Chemical Peels as a new therapeutic modality in melasma in comparison to Jessner’s solution chemical peels. Dermatol Surg 2006; 32(12): 1429-36.

Mashhadani SA, Al-Tikreety MM, Sharquie KE. Lactic acid as a new therapeutic peeling agent in melasma. Dermatol Surg 2005; 31(2): 149-54.

Shankar K, Godse K, Aurangabadkar S, Lahiri K, Mysore V, Ganjoo A et al. Evidence-based treatment for melasma: expert opinion and a review. Dermatology and therapy 2014; 4(2):165-86.

Brar KS, Sunil KG, Sanjeev U, Singh K. Comparative Efficacy of 35% Glycolic Acid and 20% Trichloroacetic Acid peels in the treatment of recalcitrant melasma. The Gulf Journal of Dermatology and Venereology 2015; 22(1): 15-20.

Amir.S, Nabi.H, Rashid.T, Haroon.T.S. Superficial chemical peel with glycolic acid in melasma: J Pak Dermatol 2005; 15(2): 130-5.

Goh CL, Lim JTE. Chemical Peels. In: Christopher E.M. Griffiths, Jonathan B, Tanya B, Robert C, Daniel C, eds. Rook’s Textbook of Dermatology, 9th edn. UK: Wiley Blackwell Science Publication; 2016: 1-13.

Javaheri SM, Handa S, Kaur I, Kumar B. Safety and efficacy of glycolic acid facial peel in Indian women with melasma. Int J Dermatol 2001; 40(5): 354–7.

Singh R, Goyal S, Ahmed QR, Gupta N, Singh S. Effect of 82% Lactic Acid in Treatment of Melasma. International Scholarly Research Notices 2014: 1-7.

Khunger N, Sarkar R, Jain RK. Tretinoin peels versus glycolic acid peels in the treatment of Melasma in dark-skinned patients. Dermatol Surg 2004; 30: 756-60


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