The frequency of autoimmune thyroid disorders in patients of pemphigus vulgaris

Farheen Hassan, Sadia Jabeen, Shehla Shaukat, Ghazala Butt, Dr. Raffad, Arsilah Erum, Ijaz Hussain

Abstract


Objective To determine the frequency of autoimmune thyroid disorders in patients of pemphigus vulgaris.

 

Methods It was cross sectional study conducted at department of dermatology, Mayo hospital, Lahore. A total of 164 patients of pemphigus vulgaris satisfying the inclusion and exclusion criteria were enrolled. The diagnosis of pemphigus vulgaris was made clinically and confirmed on biopsy while autoimmune thyroid disease was confirmed by the presence of anti-thyroid antibodies and abnormalities in thyroid function tests. Reports were assessed and autoimmune thyroid disorder was labeled.

 

Results  Out of 164 patients with pemphigus vulgaris, 114(69.5%) were males, while 50(30.5%) were females. Age range was between 20 to 70 years with mean age of 43.2±16.0 years. Among 164 patients, 9(5.5%) had auto-immune thyroid disorder, 3(33.3%) had Hashimoto thyroiditis and 6 (66.7%) had Graves’ diseas.

 

Conclusion  Pemphigus vulgaris may exist together with autoimmune thyroid diseases especially Hashimoto thyroiditis and Graves’ disease.

 


Keywords


Pemphigus vulgaris, autoimmune thyroid disorders

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References


Kuriachan D, Suresh R, Janardhanan M, Savithri V. Oral lesions: the clue to diagnosis of pemphigus vulgaris. Case Rep Dent. 2015; 2015: 593940. doi: 10.1155/2015/593940. Epub 2015 Nov 19.

Gupta VK, Kelbel TE, Nguyen D, Melonakos KC, Murrell DF, Xie Y, et al. A globally available internet-based patient survey of pemphigus vulgaris: epidemiology and disease characteristics. Dermatol Clin. 2011; 29(3): 393-404.

Mao X, Nagler AR, Farber SA, Choi EJ, Jackson LH, Leiferman KM, et al. Autoimmunity to desmocollin 3 in pemphigus vulgaris. Am J Patho. 2010; 177(6): 2724-30.

Parameswaran A, Attwood K, Sato R, Seiffert‐Sinha K, Sinha A. Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis and type I diabetes. Br J Dermatol. 2015; 172(3): 729-38.

Kavala M, Kural E, Kocaturk E, Zindanci I, Turkoglu Z, Can B. The evaluation of thyroid diseases in patients with pemphigus vulgaris. Sci World J. 2012; 2012.

Heelan K, Mahar A, Walsh S, Shear N. Pemphigus and associated comorbidities: a cross‐sectional study. Clin & Exp Dermatol. 2015; 40(6): 593-9.

Leshem YA, Katzenelson V, Yosipovitch G, David M, Mimouni D. Autoimmune diseases in patients with pemphigus and their first‐degree relatives. Int J Dermatol. 2011; 50(7): 827-31.

Daneshpazhooh M, Behjati J, Hashemi P, Shamohammadi S, Mortazavi H, Nazemi M-J, et al. Thyroid autoimmunity and pemphigus vulgaris: is there a significant association? J Am Acad Dermatol. 2010; 62(2): 349-51.

Frunza Patten S, Dijkstra JW. Associations of pemphigus and autoimmune disease with malignancy or thymoma. Int j dermatol. 1994;33(12):836-42.

Bartalena L, Bogazzi F, Chiovato L, Tanda M, Martino E. Graves’ hyperthyroidism and ophthalmopathy associated with pemphigus vulgaris: onset of thyroid autoimmune disease during chronic low-dose glucocorticoid therapy. J Endo Invest. 1997; 20(3): 155-7.

Pitoia F, Moncet D, Glorio R, Graciela Diaz A, Rodriguez Costa G, Carbia S, et al. Prevalence of thyroid autoimmunity in patients with pemphigus vulgaris. Medicina-Buenos Aires. 2005; 65(4): 307.

Ansar A, Farshchian M, Farahnaki S. Thyroid autoimmunity in Iranian patients with pemphigus vulgaris. J Eur Acad Dermatol Venereol. 2009; 23(6): 719-20.


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