Male androgenetic alopecia treated with finasteride
DOI:
https://doi.org/10.66344/jpad.18.4.2008.601Keywords:
Androgenetic alopecia, finasterideAbstract
Background Dihydrotestosterone causes micronization of scalp hair follicles, resulting in androgenetic alopecia. Finasteride inhibits type II 5α-reductase, thereby, decreasing the conversion of testosterone to dihydrotestosterone. Objective To determine the efficacy of finasteride in male androgenetic alopecia. Patients and methods 16 men from 18-42yrs of age with moderate vertex pattern hair loss received 1mg finasteride daily for 2 yrs. Efficacy was determined by patients self assessments, investigator assessment and assessment of clinical photographs. safety was assessed by clinical analysis of adverse experience if any Results After 6 months-1yr treatment, there was a significant improvement in patient, investigator and photographic assessment. Efficacy was improved and maintained throughout the second year of the study. Finasteride was generally well tolerated. Conclusion In men with male pattern hair loss finasteride 1mg for 2 yrs slowed the progression of hair fall and increased hair growth.ÂReferences
Oslen EA. Androgenetic alopecia. In: Oslen EA, ed. Disorders of Hair Growth: Diagnosis and Treatment. New York: McGraw-Hill; 1994. p. 257-83.
Bergfeld WF. Androgenetic alopecia: an autosomal dominant disorder. Am J Med 1995; 98: 955-85.
Su LH, Chen THH. Association of androgenetic alopecia with smoking and its prevalence in Asian men. Arch Dermatol 2007; 143: 1401-6.
Hamilton JB. Male hormone stimulation is prerequisite in common baldness. Am J Anat 1942; 71: 451-80.
Kauffman K. Androgens metabolism at it affects hair growth in androgenetic alopecia. Dermatol Clin 1996; 14: 697-711.
Kauffman KD. Clinical studies on the effect of oral finasteride, a type II 5 alpha reductase inhibitor on scalp hair with male pattern baldness. In: Van Neste D, Randall VA, eds. Hair Research for the Next Millennium. Amsterdam: Elsevier Science; 1996. p. 363 -5.
Hamilton JB. Patterned hair loss in man: types and incidences: Ann NY Acad Sci 1951; 53: 708-14.
Norwood OTT. Male pattern baldness: Classification and incidence. South Med J 1975; 68: 1359-70.
Barber BL, Kauffman KD, Kozloff RC et al. A hair growth questionnaire for use in the evaluation of therapeutics effects in men. J Dermatol Treat 1998; 9: 181-6.
Neste DV, Fuh V, Sanchez-Pedreno P et al. Finesteride increases anagen hairs in men with androgenetic alopecia. Br J Dermatol 2001; 143: 804-10.
Downloads
Published
How to Cite
Issue
Section
License
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.
