Frequency of autoimmune disorders in patients of alopecia areata
Keywords:
Alopecia areata, atopic dermatitis, family history, vitiligo, hypothyroidism, hyperthyroidism, diabetes mellitusAbstract
Objective To determine the frequency of autoimmune disorders associated with alopecia areata in patients presenting in a tertiary care hospital.Methods This study was conducted at the Dermatology Department, Unit II, KEMU/Mayo Hospital, Lahore.120 patients fulfilling the inclusion criteria were entered in the study during May 2013 to January 2014. After taking informed consent and recording demographic data, complete history was taken. Examination was performed and investigations were carried out where needed, for determination of factors associated with alopecia areata. Results Out of 120 patients studied, 30.8% of patients had positive family history of alopecia areata. Atopic dermatitis was found in 29.2% of patients. Vitiligo and hypothyroidism were seen in 4.2% each. Diabetes mellitus was seen in 1.7% of the cases and 0.8% were hyperthyroid. Conclusion Postive family history and atopic dermatitis were seen in one third of our patients with alopecia areata. Vitiligo and hypothyroidism were other important associations observed.References
Paus R, Olsen EA, Messenger AG. Disorders of Hair and Nails. In: Wolff K, Goldsmith LA, Katz SI et al, eds. Fitzpatrick’s Dermatology in General Medicine, 7th edn. USA: McGraw Hill, 2008: 762-65.
Messenger AG, de burker DAR, Sinclair RD. Disorders of Hair. In: Burns T, Breathnach S, Cox N, Griffiths C, eds. Rook’s Textbook of Dermatology,8th edn. London: Blackwell Science 2010; 66: 31- 8.
Chu SY, Chen YJ, Tseng WC, Lin M-W, Chen T-J, Hwang C-Y et al. Comorbidity profiles among patients with alopecia areata: the importance of onset age, a nationwide population-based study. J Am Acad Dermatol. 2011;65:949-56.
Grandolfo M, Biscazzi AM, Pipoli M. Alopecia areata and autoimmunity. G ItalDermatol Venereol. 2008;143:277-81.
Thomas EA, Kadyan RS. Alopecia areata and autoimmunity: a clinical study. Indian J Dermatol. 2008;53:70.
Ejaz A, Jameel K, Suhail M. Pattern and profile of alopecia areata in Pakistan. J Pak Assoc Dermatol. 2009;19:136-40.
Ahmed I, Nasreen S, Jehangir U, Wahid Z. Clinical Spectrum of alopecia areata and its associations with thyroid dysfunction. J Pak Assoc Dermatol. 2012;22:207-12.
Seyrafi H, Akhiani M, Abbasi H, Mirpour S, Gholamrezanezhad A. Evaluation of the profile of alopecia areata and the prevalence of thyroid function test abnormalities and serum autoantibodies in Iranian patients. BMC Dermatol. 2005; 5: 11.
Seetharam KA. Alopecia areata: An update. Indian J Dermatol Venereol Leprol. 2013; 79: 563.
Friedmann PS. Alopecia areata and autoimmunity. Br J Dermatol. 1981; 105: 153- 7.
Krishnaram AS, Saigal A, Adityan B. Alopecia areata-Vitiligo overlap syndrome: An emerging clinical variant. Indian J Dermatol Venereol Leprol. 2013; 79: 535.
Ejaz A, Jameel K, Suhail M. Pattern and profile of alopecia areata in Pakistan. J Pak Assoc Dermatol. 2009; 19: 136-40. 117
Bhat YJ, Manzoor S, Khan AR, Qayoom S. Trace element levels in alopecia areata. Indian J Dermatol Venereol Leprol. 2009; 75: 29-31.
Mane M, Nath AK, Thappa DM. Utility of dermoscopy in alopecia areata. Indian J Dermatol. 2011;56:407.
Al-Mutairi N, Eldin ON. Clinical profile and impact on quality of life: Seven years experience with patients of alopecia areata. Indian J Dermatol Venereol Leprol. 2011;77:489-93.
Yang S, Yang J, Liu JB, Wang HY, Yang Q, Gao M et al. The genetic epidemiology of alopecia areata in China. Br J Dermatol. 2004;151:16-23.
Kaur S, Sharma V, Kumar L, Kumar B. Atopy and alopecia areata in North Indians. Indian J Dermatol Venereol Leprol. 2002;68:267-9.
Goh C, Finkel M, Christos PJ, Sinha AA. Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history. J Eur Acad Dermatol Venereol. 2006;20:1055-60.
Sharma VK, Dawn G, Kumar B. Profile of alopecia areata in Northern India. Int J Dermatol. 1996;35:22-7.
Ahmed I, Nasreen S, Bhatti R. Alopecia areata in children. J Coll Physicians Surg Pak. 2007;17:587-90.
Puavilai S, Puavilai G, Charuwichitratana S, Sakuntabhai A, Sriprachya-Anunt S. Prevalence of thyroid diseases in patients with alopecia areata. Int J Dermatol. 1994;33:632-3.
Grandolfo M, Biscazzi AM, Pipoli M. Alopecia areata and autoimmunity. G ItalDermatol Venereol.2008;143:277.