Diabetic’s skin; a storehouse of infections
Keywords:
Diabetes mellitus, hyperglycemia, cutaneous infectionsAbstract
Diabetes mellitus is a major endocrine cause of morbidity and mortality all over the world. The incidence is increasing globally. Estimated number of patients with diabetes mellitus in 2030 is 366 million. In Pakistan, prevalence approaches 10% among adults and even greater number with glucose intolerance. Patients with diabetes mellitus are prone to have cutaneous infections and major underlying cause is hyperglycemia and ketoacidosis leading to immune dysfunction. These infections can get complicated and even can prove fatal if not noticed earlier or treated properly. It is important to recognize signs and symptoms of these and to either treat them appropriately or refer the patient to a dermatologist or diabetologist. This article is a brief review of clinical features, relative occurrence in diabetes mellitus, and general management of several cutaneous infections which occur more commonly, with greater severity; or with a greater risk for complications in patients with diabetes mellitus.References
Bub JL, Olerud JE. Diabetes Mellitus: In Fitzpatrick TB, Freedberg IM, Eisen AZ et al. (editors). Dermatology in General Medicine, Vol 2, 6th edn. New York: McGraw-Hill; 2003. p. 1651-55.
Wild S, Roglie G, Green A et al. Global prevalence of diabetes. Diabetes Care 2004; 27: 1047-53.
Shera ASA, Jawad FA, Maqsood AA. Prevalence of diabetes in Pakistan. Diabetes Res Clin Prac 2007; 76: 219-22.
Hattemn SV, Boots MA, Thio HB. Skin menifestations of diabetes. Cleveland Clin J Med 2008; 75: 772-87.
Nigham PK, Pande S. Pattern of dermatoses in diabetics. Indian J Dermatol Venereol Leprol 2003; 69: 83-5.
Mahajan S, Koranne RV, Sharma SK. Cutaneous manifestation of diabetes mellitus. Indian J Dermatol Venereol Leprol 2003; 69: 105-8.
Olerud JE, editor. Ellenberg & Rifkin’s Diabetes Mellitus, 6th edn. New York: McGraw Hill; 2003.
Joshi N, Caputo GM, Weitekamp MR, Karchmer AW. Infections in patients with diabetes mellitus. N Engl J Med 1999: 341: 1906-99.
Farly MM. Group B streptococcal disease in non-pregnant adults. Clin Infec Dis 2001; 33: 556-61.
Alba-Loureiro TC, Munhoz CD, Martins JO et al. Neutrophil function &metabolism in individuals with diabetes mellitus. Brazilian J Med Biol Res 2007; 40: 1037-44.
Sharkawy A, Low DE, Saginur R et al. Severe group A streptococcal soft tissue infections in Ontario. Clin Inf Dis 2002; 34: 454-60.
Oncul O, Erenoglu C, Top C et al. Necrotizing fasciitis: A life-threatening clinical disorder in uncontrolled type 2 diabetic patients. Diabetes Res Clin Pract 2008; 80: 218-23. Epub 2008 Jan 10
Eke N. Fournier’s gangrene: A review of 1726 cases. Br J Surg 2000; 87: 718.
Aananthi C, Sarayu L. A study of chronic dermatophyte infection in a rural hospital. Indian J Dermatol Venereol Leprol 2005; 71: 129.
Hsiao YC, Tsan KW, Wang TY. Rhinocerebral mucormycosis in diabetes. A case report. J Intern Med Taiwan 2002; 13: 160-4.
Hopkins MA, Treloa DM. Mucormycosis in diabetes. Am J Critical Care 1997; 6: 363-7.
