Is the Addition of Oral Biotin to PRP More Beneficial for Treating Male Pattern Hair Loss Compared to PRP Alone? A Randomized Control Trial

Abstract

Background:  Androgenetic Alopecia (AGA) is a common and progressive condition of patterned hair loss from the scalp and affects both genders with a genetic background. The onset and speed of progression varies among patients. Multiple treatment modalities are in use for the treatment of AA namely minoxidil, finasteride, etc.; however, they are associated with some unacceptable side effects. The efficacy of oral supplements is controversial in AGA. Little data is available on the role of Biotin supplementation in AGA so this trial aimed to fill this research gap. Objective:  To determine the effectiveness of oral Biotin in combination with PRP vs PRP alone in treating Androgenetic Alopecia. Methods:  This is Randomized controlled trial (Trial registration number#TCTR20250506001). One hundred and Eighty patients were enrolled in the study. Group A consisting of 90 patients received four sessions of PRP,1 month apart while Group B was treated with a similar protocol of PRP in combination with oral Biotin 2500mcg once daily for 6 months. Patients were called for monthly follow and final assessments done after 6 months using the Dermatology Quality of Life Index (DLQI) and Digital photography. Results:  The mean age in Groups A and B was 27.74±5.55&29.72±5.40 years respectively. The number of patients was comparable in both groups based on the Norwood Hamilton grading system. The family history was positive in 51.2 % of patients in Group A and 49.5% of patients in Group B. After 6 months of using DLQI and digital photography, compared to baseline, Patients in both groups gained significant hair regrowth but there was no intergroup difference (p value>0.05). Conclusions:  It is concluded that the combination of Biotin supplements with PRP gives no additional benefits in AGA patients.