Demographic and Clinicopathological Characteristics of Head Basal Cell Carcinoma: A Retrospective Study
Keywords:
Basal cell carcinoma, skin cancer, IraqAbstract
Background: Basal cell carcinoma is the common type of skin malignancies. The global annual incidence is 2.75 million cases. Ultraviolet light is one of the main risk factors. Basal cell carcinoma appears in multiple clinical and microscopic presentations and could affect any site. The head region is reported as a common area involved. Surgical intervention is the most common approach for treatment. Objective: The objective of this study is to assess the demographic and clinicopathological characteristics of head basal cell carcinoma cases. Methods: Pathological reports were reviewed to confirming diagnoses of Basal cell carcinoma in the head region from 2013 to 2023 at Al-Wasity Teaching Hospital, Iraq. From each report, clinicopathological features were recorded. The microscope slides of each case were examined to verify the diagnosis. Results: The total cases were 209 (Female: 108 and male: 98) with no significant difference between both sexes. 56.5 years was the mean age. Half of the cases were found in patients aged between 50 and 70 years. The nose appeared on the top site involved. The nodular subtype accounted for 77% of the cases. Conclusion: Basal cell carcinoma incidence did not differ between males and females, and increasing age was associated with the risk of developing the cancer. The nasal area was the most common site affected. The nodular subtype was the most prevalent subtype, which leads to a prediction of a good prognosis after treatment. A large survey covering all Iraqi governorates is needed to highlight the incidence, prevalence of basal cell carcinoma.References
Niculet E, Craescu M, Rebegea L, Bobeica C, Nastase F, Lupasteanu G, et al. Basal cell car-cinoma: Comprehensive clinical and histopa-thological aspects, novel imaging tools and thera-peutic approaches. Experimental and therapeutic medicine. 2022;23(1):1-8.
Keim U, Katalinic A, Holleczek B, Wakkee M, Garbe C, Leiter U. Incidence, mortality and trends of cutaneous squamous cell carcinoma in Germany, the Netherlands, and Scotland. European Journal of Cancer. 2023;183:60-8.
Hasan A, Kandil AM, Al-Ghamdi HS, Alghamdi MA, Nasr M, Naeem SA, et al. Sun-exposed versus sun-protected cutaneous basal cell carcinoma: clinico-pathological profile and p16 immunostain-ing. Diagnostics. 2023;13(7):1271.
Almutairi R, Al-Sabah H. Basal Cell Carcinoma: A Brief Review of Histopathological Types. Authorea Preprints. 2024.
Dika E, Scarfì F, Ferracin M, Broseghini E, Marcelli E, Bortolani B, et al. Basal cell carcinoma: a comprehensive review. International Journal of Molecular Sciences. 2020;21(15):5572.
Basset-Seguin N, Herms F. Update on the management of basal cell carcinoma. Acta Dermato-Venereologica. 2020;100(11).
Jabou SA, Al-Drobie B, Abdullah BH. Clini-copathological Analysis of 85 Cases of Basal Cell Carcinoma Variants. Journal of Oral and Dental Research. 2023;10(1).
Chang JM, Gao XM. Clinical and histopathological characteristics of basal cell carcinoma in Chinese patients. Chin Med J (Engl). 2013;126(2):211-4.
Kasumagic-Halilovic E, Hasic M, Ovcina-Kurtovic N. A clinical study of basal cell carcinoma. Medical archives. 2019;73(6):394.
Koh D, Wang H, Lee J, Chia K, Lee H, Goh C. Basal cell carcinoma, squamous cell carcinoma and melanoma of the skin: analysis of the Singapore Cancer Registry data 1968–97. British Journal of Dermatology. 2003;148(6):1161-6.
Ghanadan A, Abdollahi P, Rabet M, Naraghi Z, Abbasi MA, Moslehi H, et al. Different anatomical distribution of basal cell carcinoma subtypes in Iranian population: Association between site and subtype. Annals of dermatology. 2014;26(5):559.
Chinem VP, Miot HA. Epidemiology of basal cell carcinoma. Anais brasileiros de dermatologia. 2011;86:292-305.
Borz?cka-Sapko A, Siermontowski P, Mleczko M, Borz?cki A. Epidemiology of basal cell carcinoma–observations of one department. Polish Hyperbaric Research. 2020;71(2):55-66.
Kavoussi H, Ebrahimi A, Rezaei M, Najafi F, Zarpoosh M, Kavoussi R. Comparison of Demo-graphic and Clinicopathological Characteristics of Basal Cell Carcinoma on the Nose and Other Sites of the Face: A Cross-Sectional Study. Iranian Jour-nal of Otorhinolaryngology. 2021;33(118):257.
Vladimír B, Kullova M. Basal cell carcinoma of the skin: Topographic distribution and clinicopatho-logical differences with regards to the extent of sunlight exposure. Journal of Pakistan Association of Dermatologists. 2016;26(4):310-7.
Chang J-m, Gao X-m. Clinical and histopatholo-gical characteristics of basal cell carcinoma in Chinese patients. Chinese Medical Journal. 2013; 126(2):211-4.
Arits A, Schlangen M, Nelemans P, Kelleners?Smeets N. Trends in the incidence of basal cell carcinoma by histopathological subtype. Journal of the European Academy of Dermatology and Venereology. 2011;25(5):565-9.
George RM, Nazeer M, Criton S, Abraham UM, Francis A. Clinicopathological analysis of basal cell carcinoma–A retrospective study. Journal of Skin and Sexually Transmitted Diseases. 2021;3(1):51-5.
Pyne JH, Myint E, Barr EM, Clark SP, David M, Na R, et al. Superficial basal cell carcinoma: A comparison of superficial only subtype with superficial combined with other subtypes by age, sex and anatomic site in 3150 cases. Journal of cutaneous pathology. 2017;44(8):677-83.
