Prevalance of Metabolic Syndrome in men with androgenetic alopecia: A cross-sectional study
Keywords:
Androgenetic alopecia, metabolic syndromeAbstract
Introduction In the last twenty years, evidence has revealed a connection between androgenetic alopecia and metabolic syndrome, along with its related conditions such as cardiovascular diseases, hypertension, and insulin resistance. Metabolic syndrome is characterized by the presence of hypertension, abdominal obesity, dyslipidemia, impaired fasting glycemia, and insulin resistance, and it has been linked to an elevated risk of developing cardiovascular diseases. The aim of this study was to assess the prevalence of metabolic syndrome in men with androgenetic alopecia. Methods This cross-sectional study was done at the Department of Dermatology, Bahawal Victoria Hospital in Bahawalpur from August 2, 2018 to February 1, 2019.The study involved 95 male participants aged between 20 and 50 with androgenetic alopecia. Exclusions were made for individuals with alopecia areata or psoriasis, those with chronic renal failure (CRF) or chronic liver disease (CLD), and those undergoing radiotherapy or chemotherapy. Informed written consent was obtained, and the researchers assessed five components of metabolic syndrome. Results The study included participants between the ages of 20 and 50, with an average age of 34.07±6.36 years. Most participants, 61 individuals (64.21%), were between 20 to 35 years of age. The average duration of androgenetic alopecia was 6.31±2.46 months, while the mean height, weight, and BMI were 166.19±11.24 cm, 76.33±7.57 kg, and 26.19±4.57 kg/m², respectively. The study found that 16 individuals (16.84%) with androgenetic alopecia had metabolic syndrome. Conclusion This study concluded that there is a substantial prevalence of metabolic syndrome among men with androgenetic alopecia.References
References
Mosbeh A, Ismail M, Elgendy A. Dyslipidemia in patients with early onset androgenetic alopecia and risk of coronary artery disease. Gulf J Dermatol Venereol. 2014;21(1):23-8.
Nargis T, Bejai V, Pinto M, Shenoy MM. Early onset androgenetic alopecia in men and associated risk factors: a hospital based study. Int J Res Dermatol. 2017;3:267-71.
Yeo IK, Jang WS, Min PK, Cho HR, Cho SW, Hong NS, et al. An epidemiological study of androgenic alopecia in 3114 Korean patients. Clin Exp Dermatol. 2014;39:25-9.
Bakry OA, Shoeib MA, El Shafiee MK, Hassan A. Androgenetic alopecia, metabolic syndrome, and insulin resistance: Is there any association? A case-control study. Indian Dermatol Online J. 2014;5:276-81.
Hu Y, Zhu Y, Lian N ,Chen M ,Bartke A, Yuan R. Metabolic syndrome and skin diseases. Front Endocrinol. 2019;10:788.
Kelly Y, Blanco A, Tosti A. Androgenetic alopecia : an update of treatment options. Drugs. 2016;76:1349-64.
Banger HS, Malhotra SK, Singh S, Mahajan M. Is early onset androgenic alopecia a marker of metabolic syndrome and carotid artery atherosclerosis in young Indian male patients? Int J Trichol. 2015;7:141–7.
Krupa Shankar D, Chakravarthi M, Shilpakar R. Male androgenetic alopecia: Population-based study in 1,005 subjects. Int J Trichol. 2009;1:131–3.
Lolli F, Rossi A, et al. Androgenetic alopecia: a review. Endocrine. 2017;57(1):9-17.
Lie C, Liew C, Oon H. Alopecia and the metabolic syndrome. Clin Dermatol. 2018;36(1):54-61.
Banger HS, Malhotra SK, Singh S, Mahajan M. Is early onset androgenic alopecia a marker of metabolic syndrome and carotid artery atherosclerosis in young Indian male patients? Int J Trichol. 2015;7:141–7.
Su LH, Chen LS, Lin SC, Chen HH. Association of androgenetic alopecia with mortality from diabetes mellitus and heart disease. JAMA Dermatol. 2013;149:601–6.
Ahouansou S, Le Toumelin P, Crickx B, Descamps V. Association of androgenetic alopecia and hypertension. Eur J Dermatol. 2007;17:220–2.
Matilainen V, Koskela P, Keinänen-Kiukaanniemi S. Early androgenetic alopecia as a marker of insulin resistance. Lancet. 2000;356:1165–6.
Sadighha A, Zahed GM. Evaluation of lipid levels in androgenetic alopecia in comparison with control group. J Eur Acad Dermatol Venereol. 2009;23:80–1.
Mosley JG, Gibbs AC. Premature grey hair and hair loss among smokers: A new opportunity for health education? BMJ. 1996;313:1616.
Hawk E, Breslow RA, Graubard BI. Male pattern baldness and clinical prostate cancer in the epidemiologic follow-up of the first national health and nutrition examination survey. Cancer Epidemiol Biomarkers Prev. 2000;9:523–7.
Oh BR, Kim SJ, Moon JD, Kim HN, Kwon DD, Won YH, et al. Association of benign prostatic hyperplasia with male pattern baldness. Urology. 1998;51:744–8.
Grundy SM, Brewer HB, Jr, Cleeman JI, Smith SC, Jr, Lenfant C, et al. American Heart Association. Definition of metabolic syndrome: Report of the national heart, lung, and blood institute/American Heart Association Conference on scientific issues related to definition. Circulation. 2004;109:433–8.
Tilwani MR, Dogra NK, Dogra D, Rather SR, Rather PA. Severe androgenetic alopecia as a maker of metabolic syndrome in male patients of androgenetic alopecia: a hospital based case control study. Int J Res Med Sci. 2017;5:601-6.
Thakare SA, Singh A. Early-onset male androgenetic alopecia and metabolic syndrome: are there associated. Int J Recent Surg Med Sci. 2016;2(1):5-9.
Gopinath H, Upadya GM. Metabolic syndrome in androgenic alopecia. Indian J Dermatol Venereol Leprol. 2016;82:404-8.
Gok SO, Belli AK, Dervis E. Is there really relationship between androgenetic alopecia and metabolic syndrome. Dermatol Res Pract. 2015;9:80310-14.
Arias-Santiago S, Gutiérrez-Salmerón MT, Castellote-Caballero L, BuendÍa-Eisman A, Naranjo-Sintes R. Androgenetic alopecia and cardiovascular risk factors in men and women: A comparative study. J Am Acad Dermatol. 2010;63:420-9.
Chakrabarty S, Hariharan R, Gowda D, Suresh H. Association of premature androgenetic alopecia and metabolic syndrome in a young Indian population. Int J Trichol. 2014;6:50-3.
Pengsalae N, Tanglertsampan C, Phichawong T, Lee S. Association of early-onset androgenetic alopecia and metabolic syndrome in Thai men:a case-control study. J Med Assoc Thai. 2013;96:947-51.
Caro-Chang LAM, Gervasio MKR, yap-Silva C. Androgenetic alopecia and its association with metabolic syndrome: a systemic review and meta-analysis. Acta Medica Philippina. 2019;53:122-31.
