Efficacy of platelet rich plasma combined with narrow band UVB in the treatment of vitiligo
Keywords:
Chronic stable Vitiligo, Efficacy of platelet rich plasma in vitiligo, combination of PRP and NBUVB, vitiligo area severity index (VASI), Vitiligo treatment modalitiesAbstract
Objective To determine the efficacy of PRP + NBUVB in combination in the treatment of vitiligo. Methods This longitudinal interventional study was carried out at the Dermatology department, FJMU, Lahore, during January 30 - July 30, 2018. After obtaining informed consent and approval from the Institutional Ethical Committee, 73 patients with stable, non-segmental vitiligo were enrolled. NBUVB (311-315 nm) treatment was administered twice a week for a maximum of 4 months or until complete recovery. In addition to UVB therapy, all participants received PRP injections. The PRP was prepared following standard procedures and injected intradermally into the marked lesions using an insulin syringe. 0.1 cc of PRP was injected per point with 2 cm spacing between each injection. The injections were given every two weeks for a total of 4 months. Treatment efficacy was evaluated according to the operational definition, and all data were collected by the researcher. Results Total number of patients was 73. There were 27 (36.99%) male and 46 (63.01%) female cases. The mean age of patients was 35.42±14.03 years with minimum and maximum age as 15 and 60 years. The mean VASI at baseline and at 4th month was 39.29±14.82 and 72.41±15.13 respectively. According to operational definition, 62 (84.93%) cases had efficacy of treatment while 11 (15.07%) cases did not meet efficacy criteria. Conclusion Combination of PRP+NBUVB is efficacious in treating vitiligo and shortens the duration of NBUVB therapy and increases the patient compliance.References
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