Comparison of efficacy of topical retinoid with topical steroids in the treatment of oral lichen planus in a tertiary care hospital Quetta
Keywords:
Topical retinoids with topical steroids, Oral lichen planus, Post stratification T TestAbstract
Objective To compare the efficacy of topical retinoids with topical steroids in the treatment of oral lichen planus presented in tertiary care hospital Quetta.  Methods The study was designed and was conducted in Dermatology department Bolan Medical College Hospital/ Sandeman provincial hospital, Quetta. The approval of the study was taken from the institutional ethical review board. The duration of study was six months, from 15. June 2020 to 15 January 2021.  Results A total of 82 patients were selected through non-probability sampling. The patients were included after complete examination and history taking. Patients were either diagnosed clinically or lesional biopsy was taken. The patients were grouped into two groups, one was named Group R (for topical retinoids), and another was named Group S (for topical steroids). Data was analyzed using SPSS version 25. Post stratification T test was applied by taking P<0.05 as level of significance. The total number of patients was 82, all with clinical diagnosis of lichen planus. The average age of patients was 41.1± 9.4 years.  Conclusion The steroid group showed significantly low post treatment scores as compared to the Retinoid group; (2.7±0.8 vs. 4.2±0.8; P=0.000). In addition, the steroid group showed significantly low post treatment symptoms score as compared to retinoid group (2.6±1.0 vs. 5.9±1.1; P= 0.000). Topical steroid therapy is more effective as compared to topical retinoids in terms of signs and symptoms in patients of lichen planus. ÂReferences
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