Specific Dermatoses of Pregnancy: Unraveling the Enigma

Specific Dermatoses of Pregnancy


  • Yasaan Saaqib Gujranwala Medical College
  • Shazia Saqib Allama Iqbal Medical College Lahore
  • Nabeela Shahzadi Gujranwala Medical College Gujranwala
  • Zahid Tahir Gujranwala Medical College Gujranwala
  • Nadia Ali Azfar Gujranwala Medical College, Gujranwala.


Atopic eruption of pregnancy, polymorphic eruption of pregnancy, Pemphigoid gestationis, Generalized pustular psoriasis of pregnancy, Intrahepatic cholestasis of pregnancy


Pregnancy represents a transformative phase in a woman's life, often accompanied by distinct dermatological conditions. These skin conditions comprise a spectrum of inflammatory disorders that emerge exclusively during pregnancy, triggered by the dynamic physiological and hormonal changes. These dermatoses encompass atopic eruptions of pregnancy (AEP), polymorphic eruptions of pregnancy (PEP), gestational pemphigoid (GP), obstetric cholestasis (OC), and pustular psoriasis of pregnancy (PPP). Several of these specific dermatoses of pregnancy not only impact the mother's skin but also carry potential risks for the fetus, including prematurity, intrauterine growth restriction (IUGR), and, in severe cases, fetal demise. Unfortunately, there exists limited knowledge regarding the pathogenesis, clinical manifestations and management of these specific pregnancy-related dermatoses, not only among general practitioners, who typically serve as the initial point of contact for pregnant patients, as well as dermatologists and obstetricians to whom patients are often referred. This narrative review aims to provide healthcare professionals with a comprehensive understanding of these pregnancy-specific dermatoses. By enhancing awareness and knowledge about these conditions, we aim to equip healthcare providers with the necessary information to make informed decisions and deliver improved care to pregnant women. Ultimately, this collaborative effort strives to contribute to enhanced pregnancy outcomes and the well-being of both mothers and their unborn children.  

Author Biographies

Yasaan Saaqib, Gujranwala Medical College

Resident Dermatologist, Department of Dermatology, Gujranwala Medical College, Gujranwala.

Shazia Saqib, Allama Iqbal Medical College Lahore

Assistant Professor of Obstetrics and Gynaecology Unit-II, Allama Iqbal Medical College/Jinnah Hospital, Lahore.

Nabeela Shahzadi, Gujranwala Medical College Gujranwala

Assisstant Professor of Dermatology, Gujranwala Medical College, Gujranwala.

Zahid Tahir, Gujranwala Medical College Gujranwala

Assisstant Professor of Dermatology, Gujranwala Medical College, Gujranwala.

Nadia Ali Azfar, Gujranwala Medical College, Gujranwala.

Head/ Professor of Department of Dermatology, Department of Dermatology, Gujranwala Medical College, Gujranwala.


Naz S, Khan S, . M, Abbasi S, . Y, Muzaffar Ali Joyo R. A Study of Specific Dermatoses and Skin Disease Affected by Pregnancy. Pakistan J Med Heal Sci. 2022;16(3):1157–9.

Sachdeva S. The dermatoses of pregnancy. Indian J Dermatol. 2008;53(3):103–5.

Kurien G, Badri T. Dermatoses of Pregnancy. 2023;

Vora R, Gupta R, Mehta M, Chaudhari A, Pilani A, Patel N. Pregnancy and skin. J Fam Med Prim Care. 2014;3(4):318.

Stefaniak AA, Pereira MP, Zeidler C, Ständer S. Pruritus in Pregnancy. Am J Clin Dermatol [Internet]. 2022;23(2):231–46. Available from: https://doi.org/10.1007/s40257-021-00668-7

Thomas S, Rajan U, George S, George M. Postpartum pemphigoid gestationis. Indian J Dermatol. 2012;57(2):146–8.

Kroumpouzos G, Cohen LM. Dermatoses of pregnancy. J Am Acad Dermatol. 2001;45(1):1–22.

Holmes RC, Black MM. The specific dermatoses of pregnancy. J Am Acad Dermatol. 1983;8(3):405–12.

Shornick JK, Black MM. Secondary autoimmune diseases in herpes gestationis (pemphigoid gestationis). J Am Acad Dermatol. 1992;26(4):563–6.

Ambros-Rudolph CM, Müllegger RR, Vaughan-Jones SA, Kerl H, Black MM. The specific dermatoses of pregnancy revisited and reclassified: Results of a retrospective two-center study on 505 pregnant patients. J Am Acad Dermatol. 2006;54(3):395–404.

Romiti R, Hirayama AL da S, Arnone M, Magalhães RF. Generalized pustular psoriasis (von Zumbusch). An Bras Dermatol. 2022;97(1):63–74.

Sävervall C, Sand FL, Thomsen SF. Pemphigoid gestationis: Current perspectives. Clin Cosmet Investig Dermatol. 2017;10:441–9.

Maglie R, Quintarelli L, Verdelli A, Fabbri P, Antiga E, Caproni M. Specific dermatoses of pregnancy other than pemphigoid gestationis. G Ital di Dermatologia e Venereol. 2019;154(4):286–98.

Vaughan Jones SA, Black MM. Pregnancy dermatoses. J Am Acad Dermatol. 1999;40(2 Pt 1):233–41.

J. Ring, B. Przybilla TR. Handbook of Atopic Eczema. Handb Atopic Eczema. 2006;

Roger D, Vaillant L, Fignon A, Pierre F, Bacq Y, Brechot JF, et al. Specific Pruritic Diseases of Pregnancy: A Prospective Study of 3192 Pregnant Women. Arch Dermatol. 1994;130(6):734–9.

Ravelli FN, Goldust M, Kroumpouzos G. Assessment of prurigo of pregnancy in patients without atopic background. Int J Women’s Dermatology. 2020;6(5):384–9.

Cobo MF, Santi CG, Maruta CW, Aoki V. Pemphigoid gestationis: Clinical and laboratory evaluation. Clinics. 2009;64(11):1043–7.

Kroumpouzos G, Cohen LM. Pruritic folliculitis of pregnancy. J Am Acad Dermatol. 2000;43(1):132–4.

Sun K. Special types of folliculitis which should be differentiated from acne. Dermatoendocrinol. 2018;9(1):e1356519.

Kroumpouzos G, Cohen LM. Specific dermatoses of pregnancy: An evidence-based systematic review. Am J Obstet Gynecol. 2003;188(4):1083–92.

Hassan I, Bashir S, Taing S. A clinical study of the skin changes in pregnancy in Kashmir valley of north India: A hospital based study. Indian J Dermatol. 2015;60(1):28–32.

Zoberman E, Farmer ER. Pruritic folliculitis of pregnancy. Obstet Gynecol Surv. 1981;36(9):484–5.

Kroumpouzos G. Specific dermatoses of pregnancy: Advances and controversies. Expert Rev Dermatol. 2010;5(6):633–48.

Vaughan Jones SA, Hern S, Nelson-Piercy C, Seed PT, Black MM. A prospective study of 200 women with dermatoses of pregnancy correlating clinical findings with hormonal and immunopathological profiles. Br J Dermatol. 1999;141(1):71–81.

Akhtar NH, Khosravi-Hafshejani T, Akhtar D, Dhadwal G, Kanani A. The use of dupilumab in severe atopic dermatitis during pregnancy: a case report. Allergy, Asthma Clin Immunol [Internet]. 2022;18(1):1–3. Available from: https://doi.org/10.1186/s13223-022-00650-w

Pardo EF, Fulgencio-Barbarin J. Polymorphic eruption of pregnancy. Progresos Obstet y Ginecol. 2020;63(5):278.

Chouk Chourouk ; Litaiem Noureddine. Pruritic urticarial papules and plaques of pregnancy [Internet]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539700/

Elling S V., McKenna P, Powell FC. Pruritic urticarial papules and plaques of pregnancy in twin and triplet pregnancies. J Eur Acad Dermatology Venereol. 2000;14(5):378–81.

Mehedintu C, Isopescu F, Ionescu OM, Petca A, Bratila E, Cirstoiu MM, et al. Diagnostic Pitfall in Atypical Febrile Presentation in a Patient with a Pregnancy-Specific Dermatosis—Case Report and Literature Review. Med. 2022;58(7).

Taylor D, Pappo E, Aronson IK. Polymorphic eruption of pregnancy. Clin Dermatol. 2016;34(3):383–91.

de Lourdes Ribeiro de Carvalho M, Magalhães GM, Leite HV. Update on specific dermatoses of pregnancy. Rev Assoc Med Bras. 2023;69(1992).

Zejnullahu VA, Zejnullahu VA. Polymorphic eruption of pregnancy. Dermatology Reports. 2023;15(1):8–13.

Ceryn J, Siekierko A, Skibińska M, Doss N, Narbutt J, Lesiak A. Pemphigoid gestationis – case report and review of literature. Clin Cosmet Investig Dermatol. 2021;14(Cdc):665–70.

Hallaji Z, Mortazavi H, Ashtari S, Nikoo A, Abdollahi M, Nasimi M. Pemphigoid gestationis: Clinical and histologic features of twenty-three patients. Int J Women’s Dermatology. 2017;3(2):86–90.

Ambros-Rudolph CM. Dermatoses of pregnancy - Clues to diagnosis, fetal risk and therapy. Ann Dermatol. 2011;23(3):265–75.

Jenkins RE, Hern S, Black MM. Clinical features and management of 87 patients with pemphigoid gestationis. Clin Exp Dermatol. 1999;24(4):255–9.

Pusl T, Beuers U. Intrahepatic cholestasis of pregnancy. Orphanet J Rare Dis. 2007;2(1):1–6.

Sumit K, Ajay K, Varma SP. Pregnancy and skin. J Obstet Gynecol India. 2012;62(3):268–75.

Ozkan S, Ceylan Y, Ozkan OV, Yildirim S. Review of a challenging clinical issue: Intrahepatic cholestasis of pregnancy. World J Gastroenterol. 2015;21(23):7134–41.

Geenes V, Williamson C. Intrahepatic cholestasis of pregnancy. World J Gastroenterol. 2009;15(17):2049–66.

Martinefski M, Contin M, Lucangioli S, Di Carlo MB, Tripodi V. In Search of an Accurate Evaluation of Intrahepatic Cholestasis of Pregnancy. Scientifica (Cairo). 2012;2012(Cdc):1–6.

Ovadia C, Seed PT, Sklavounos A, Geenes V, Di Illio C, Chambers J, et al. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. Lancet. 2019;393(10174):899–909.

Trivedi MK, Vaughn AR, Murase JE. Pustular psoriasis of pregnancy: Current perspectives. Int J Womens Health. 2018;10:109–15.

Ennouri M, Bahloul E, Sellami K, Marrakchi S, Fakhfakh F, Turki H, et al. Pustular psoriasis of pregnancy: Clinical and genetic characteristics in a series of eight patients and review of the literature. Dermatol Ther. 2022;35(8).

Seishima M, Fujii K, Mizutani Y. Generalized Pustular Psoriasis in Pregnancy: Current and Future Treatments. Am J Clin Dermatol. 2022;23(5):661–71.

Pitch M, Somers K, Scott G, Tausk F, Mercurio MG. A case of pustular psoriasis of pregnancy with positive maternal-fetal outcomes. Cutis. 2018;101(4):278–80.




How to Cite

Saaqib Y, Saqib S, Shahzadi N, Tahir Z, Azfar NA. Specific Dermatoses of Pregnancy: Unraveling the Enigma: Specific Dermatoses of Pregnancy. J Pak Assoc Dermatol [Internet]. 2024May6 [cited 2024May20];34(1):262-7. Available from: https://jpad.com.pk/index.php/jpad/article/view/2707



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