A comparative study between topical aluminium chloride hexahydrate 20% solution (Driclor) with potassium permanganate KMnO4 solution and topical zinc acetate with erythromycin (Zineryt solution) in treatment of axillary bromhidrosis
Keywords:Bromhidrosis, Driclor, Zineryt, Potassium permanganate
AbstractObjective To evaluate and compare effectiveness of topical combined driclor solution with Potassium permanganate KMnO4 solution (1:10000) and topical zinc acetate with erythromycin (Zineryt solution) in treatment of axillary bromhidrosis. Methods Across-sectional comparative study was carried out from march 2021 to march 2022. Group A: 25 patients treated with Driclor single night application on dry clean axilla with KMnO4 solution (1:10000) single application at day time for 30 min then wash with tape water. Group B: 25 patients treated with topical zineryt solution twice daily applications for 12 weeks. Follow up of both groups for 12 weeks after stopping the treatment. Results There is no significant difference in mean of severity score for axillary bromhidrosis between group A and group B, before, after 6 weeks and after 12weeks.patients in group A show higher good satisfaction (72%) than group B(12%).during follow up period relapse rate was higher (72% (in group B in compare with relapse rate in group A (16%),percent reduction (response rate) for mean of severity score was 78.37±5.88% after 6 weeks and 91.89±35.29% after 12 weeks in group A and 61.76±4.08 % after 6 weeks and79.41±6.12% after 12 weeks in group B. Conclusion Both protocol was effective in treatment of axillary bromhidrosis, but topical driclor with Potassium permanganate KMnO4 solution (1:10000) show higher response rate and lower relapsing rate when compare with topical zineryt solution.
(1) Kao TH, Pan HC, Sun MH, Chang CS, Yang DY, Wang YC. Upper thoracic sympathectomy for axillary osmidrosis or bromidrosis. Journal of Clinical Neuroscience. 2004 Sep 1;11(7):719-22.
(2) Morioka D, Ohkubo F, Amikura Y. Clinical features of axillary osmidrosis:A retrospective chart review of 723 J apanese patients. The Journal of dermatology. 2013 May;40(5):384-8.
(3) James AG, Austin CJ, Cox DS, Taylor D, Calvert R. Microbiological and biochemical origins of human axillary odour. FEMS microbiology ecology. 2013 Mar 1;83(3):527-40.
(4) Wang T, Dong J, He J. Long-term safety and efficacy of botulinum toxin A treatment in adolescent patients with axillary bromhidrosis. Aesthetic plastic surgery. 2018 Apr;42:560-4.
(5) Kunachak S, Wongwaisayawan S, Leelaudomlipi P. Noninvasive treatment of bromidrosis by frequency-doubled Q-switched Nd: YAG laser. Aesthetic plastic surgery. 2000 May;24:198-201.
(6) Lee KG, Kim SA, Yi SM, Kim JH, Kim IH. Subdermal coagulation treatment of axillary bromhidrosis by 1,444 nm Nd: YAG laser: a comparison with surgical treatment. Annals of Dermatology. 2014 Feb 1;26(1):99-102.
(7) HUANG YH, YANG CH, CHEN YH, CHEN CH, LEE SH. Reduction in osmidrosis using a suction‐assisted cartilage shaver improves the quality of life. Dermatologic surgery. 2010 Oct;36(10):1573 -7.
(8) Qian JG, Wang XJ. Effectiveness and complications of subdermal excision of apocrine glands in 206 cases with axillary osmidrosis. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2010 Jun 1;63(6):1003 -7.
(9) STILLIANS AW. The control of localized hyperhidrosis. Journal of the American Medical Association. 1916 Dec 30;67(27):2015 -6.
(10) Holzle E. Topical pharmacological treatment. CURRENT PROBLEMS IN DERMATOLOGY-BASEL-. 2002 Jan 1;30:30-43.
(11) Li W, Liu M, inventors. Method and composition for preventing sweat-related odor. United States patent US 6,426,061. 2002 Jul 30.
(12) Sánchez-Saldaña,L,SáenzAnduaga,E.Antisépticosy desinfectantes. Dermatol Peru. 2005;15:82–103.
(13) He J, Wang T, Zhang Y, Dong J. Surgical treatment of axillary bromhidrosis by combining suction -curettage with subdermal undermining through a miniature incision. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2018 Jun 1;71(6):913-8.
(14) Kunachak S, Wongwaisayawan S, Leelaudomlipi P. Noninvasive treatment of bromidrosis by frequency-doubled Q-switched Nd: YAG laser. Aesthetic plastic surgery. 2000 May;24:198-201.