High serum resistin levels correlate with the increased severity of psoriasis vulgaris

Authors

  • Venny Tandyono Department of Dermatology and Venereology, Medical Faculty, Widya Mandala Catholic University Surabaya, Indonesia
  • Dave Gerald Oenatra Department of Dermatology and Venereology, Medical Faculty, Widya Mandala Catholic University Surabaya, Indonesia
  • Prima Sanjiwani Saraswati Sudarsa Department of Dermatology and Venereology, Medical Faculty, Udayana University, Prof dr. I.G.N.G Ngoerah General Hospital Denpasar, Bali, Indonesia
  • Nyoman Yoga Maya Pramita Department of Dermatology and Venereology, Medical Faculty, Udayana University, Prof dr. I.G.N.G Ngoerah General Hospital Denpasar, Bali, Indonesia

Keywords:

Resistin, Psoriasis vulgaris, PASI score, metabolic syndrome

Abstract

Background Psoriasis is a chronic inflammatory skin disorder characterized by an increase in epidermal turnover and inflammation of the dermis. Resistin is one of the adipokines that promotes the production of proinflammatory mediators involved in the pathogenesis of psoriasis. This study aimed to assess the correlation between serum resistin levels with the severity of psoriasis vulgaris.   Methods The disease severity was recorded based on Psoriasis Area and Severity Index (PASI) score, and serum resistin levels were obtained for each subject. The independent t test and One-Way ANOVA were applied for comparative analysis and the Pearson test was used to measure correlation analysis.   Results Serum resistin levels didn’t differ significantly between men and women (p=0.998) or also between the normal, overweight and obese subjects (p=0.624). Serum resistin levels were significantly higher in subjects with psoriasis vulgaris compared with controls (p<0.001). High serum resistin levels were markedly correlated (r=0.848; p<0.001) with the increased severity of psoriasis vulgaris based on the Psoriasis Area Severity Index (PASI) scores.   Conclusion Serum resistin levels mediates the degree of inflammation of psoriasis and correlates with the severity of psoriasis vulgaris.  

References

Słuczanowska-Głabowska S, Staniszewska M, Marchlewicz M, Duchnik E, Łuczkowska K, Safranow K, et al. Adiponectin, leptin and resistin in patients with psoriasis. J Clin Med. 2023; 12(2):663.

Gudjonsson, J.E; Elder, J.T. Psoriasis. In: Wolff K, Goldsmith LA, Katz SI, eds. Fitzpatrick’s Dermatology in General Medicine 2012. 8th ed. New York: McGraw Hill. p. 174-93.

Baran A, Flisiak I, Jaroszewicz J, Świderska M. Effect of psoriasis activity on serum adiponectin and leptin levels. Postepy Dermatol Alergol. 2015;32(2):101-6.

Wolk K, Sabat R. Adipokines in psoriasis: An important link between skin inflammation and metabolic alterations. Rev Endocr Metab Disord. 2016;17(3):305-17.

Winer S, Winer DA. The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance. Immunol Cell Biol. 2012; 90(8):755-62.

Gerdes S, Rostami-Yazdi M, Mrowietz U. Adipokines and psoriasis. Exp Dermatol. 2011;20: 81-7.

Coimbra S, Catarino C, Santos-Silva A. The triad psoriasis-obesity-adipokine profile. J Eur Acad Dermatol Venereol. 2016; 30(11):1876-85.

Filková M, Haluzík M, Gay S, Senolt L. The role of resistin as a regulator of inflammation: Implications for various human pathologies. Clin Immunol. 2009; 133(2):157-70.

Arnold KA, Treister AD, Lio PA, Alenghat FJ. Association of atherosclerosis prevalence with age, race, and traditional risk factors in patients with psoriasis. JAMA Dermatol. 2019;155(5):622–3.

Jung KJ, Kim TG, Lee JW, Lee M, Oh J, Lee SE, et al. Increased risk of atherosclerotic cardiovascular disease among patients with psoriasis in Korea: A 15-year nationwide population-based cohort study. J Dermatol. 2019;46(10):859-66.

Parisi R, Symmons DP, Griffiths CE, Ashcroft DM. Identification and Management of Psoriasis and Associated Comorbidity (IMPACT) project team. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol. 2013; 133(2):377-85.

Kuchekar AB, Pujari RR, Kuchekar SB, Dhole SN, Mule PM. Psoriasis: A Comprehensive Review. Int J Pharm Life Sci. 2011;2(6):857-77.

Gupta R, Debbaneh MG, Liao W. Genetic epidemiology of Psoriasis. Curr Dermatol Rep. 2014;3(1):61-78.

Guillet C, Seeli C, Nina M, Maul LV, Maul JT. The impact of gender and sex in psoriasis: What to be aware of when treating women with psoriasis. Int J Womens Dermatol. 2022;8(2):e010.

Tseng HW, Lin HS, Lam HC. Co-morbidities in psoriasis: a hospital-based case-control study. J Eur Acad Dermatol Venereol. 2013;27(11):1417-25.

Cemil BC, Cengiz FP, Atas H, Ozturk G, Canpolat F. Sex hormones in male psoriasis patients and their correlation with the Psoriasis Area and Severity Index. J Dermatol. 2015;42(5):500-3.

Ceovic R, Mance M, Bukvic Mokos Z, Svetec M, Kostovic K, Stulhofer Buzina D. Psoriasis: female skin changes in various hormonal stages throughout life-puberty, pregnancy, and menopause. Biomed Res Int. 2013;2013:571912.

Pennell LM, Galligan CL, Fish EN. Sex affects immunity. J Autoimmun. 2012;38(2-3):J282-91.

Arnold WP, Pennings BJ, van de Kerkhof PC. The induction of epidermal ornithine decarboxylase following UV-B irradiation is inhibited by estriol. Acta Derm Venereol. 1993;73(2):92-3.

Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB, Gelfand JM. Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol. 2006; 55(5):829-35.

Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, et al. Circulating adipokine levels in Portuguese patients with psoriasis vulgaris according to body mass index, severity and therapy. J Eur Acad Dermatol Venereol. 2010;24(12):1386-94.

Sobhan M, Farshchian M. Associations between body mass index and severity of psoriasis. Clin Cosmet Investig Dermatol. 2017;10:493-8.

Bardazzi F, Balestri R, Baldi E, Antonucci A, De Tommaso S, Patrizi A. Correlation between BMI and PASI in patients affected by moderate to severe psoriasis undergoing biological therapy. Dermatol Ther. 2010;23 Suppl 1:S14-9.

Stofkova A. Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity. Endocr Regul. 2010;44(1):25-36.

Jamaluddin MS, Weakley SM, Yao Q, Chen C. Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br J Pharmacol. 2012;165(3):622-32.

Tarkin JM, Rudd JH. Psoriasis: More than just skin deep. Arterioscler Thromb Vasc Biol. 2015;35:2487-8.

Acar EM, İlter N, Elbeg Ş. Association of leptin, resistin, and high-molecular-weight adiponectin levels with psoriasis area and severity index scores, obesity, and insulin resistance in psoriasis patients. Dermatol Sin. 2019;37:33-9.

Coban M, Tasli L, Turgut S, Özkan S, Tunç Ata M, Akın F. Association of Adipokines, Insulin Resistance, Hypertension and Dyslipidemia in Patients with Psoriasis Vulgaris. Ann Dermatol. 2016;28(1):74-9.

Monteleone G, Pallone F, MacDonald TT, Chimenti S, Costanzo A. Psoriasis: from pathogenesis to novel therapeutic approaches. Clin Sci (Lond). 2011;120(1):1-11.

Kizilarslanoğlu MC, Kara Ö, Yeşil Y, Kuyumcu ME, Öztürk ZA, Cankurtaran M, et al. Alzheimer disease, inflammation, and novel inflammatory marker: resistin. Turk J Med Sci. 2015;45(5):1040-6.

Pina T, Genre F, Lopez-Mejias R, Armesto S, Ubilla B, Mijares V, et al. Relationship of leptin with adiposity and inflammation and resistin with disease severity in psoriatic patients undergoing anti-TNF-alpha therapy. J Eur Acad Dermatol Venereol. 2015; 29(10):1995-2001.

Hussein M, Mohamed A, Ibrahim M, Mohamed S, Lamiaa N. Serum resistin level among non obese patients with psoriasis vulgaris. Gulf J Dermatol Venereol 2017; 24(1):31-6.

Robati RM, Partovi-Kia M, Haghighatkhah HR, Younespour S, Abdollahimajd F. Increased serum leptin and resistin levels and increased carotid intima-media wall thickness in patients with psoriasis: is psoriasis associated with atherosclerosis? J Am Acad Dermatol. 2014;71(4):642-8.

Johnston A, Arnadottir S, Gudjonsson JE, Aphale A, Sigmarsdottir AA, Gunnarsson SI, et al. Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation. Br J Dermatol. 2008; 159(2):342-50.

Heller MM, Lee ES, Koo JY. Stress as an influencing factor in psoriasis. Skin Therapy Lett. 2011;16(5):1-4.

Downloads

Published

2024-07-02

How to Cite

1.
Tandyono V, Oenatra DG, Sudarsa PSS, Pramita NYM. High serum resistin levels correlate with the increased severity of psoriasis vulgaris. J Pak Assoc Dermatol [Internet]. 2024Jul.2 [cited 2024Oct.5];34(3):709-17. Available from: https://jpad.com.pk/index.php/jpad/article/view/2588

Issue

Vol. 34 No. 3 (2024): July-September

Section

Original Articles