Effects of combine treatment of tressfix and PRP on the levels of different micro ribonucleic acids among seborrheic eczema patients

Authors

  • Uzma Dost Muhammad Rajar Department of Dermatology, Isra University, Hala Road, Hyderabad, Sindh
  • Amin Fahim Professor of Pathology, People's University of Medical and Health Sciences for women, Shaheed Benazirabad.
  • Navaid Kazi Department of Physiology, Isra University, Hala Road, Hyderabad, Sindh

Keywords:

Platelet-Rich plasma, seborrheic dermatitis, MicroRNAs

Abstract

Introduction The research aid in the identification of individual micro Ribonucleic Acids (miRNA) linked to the beneficial tissue healing responses found in patients receiving the medication. Hence the study is aimed to determine the effects of PRP and tressfix serum on the levels of miRNA among seborrheic eczema patients.   Methods The research comprised both male and female individuals between the ages of 18 and 65 who had mild to moderate seborrheic eczema. Participants were either unresponsive to traditional therapy or resistive to them. Individuals with immune-related diseases, bleeding disorders, active skin infections, serious medical illnesses, allergies to PRP or tressfix serum components, and those who were pregnant or nursing were not eligible.   Results The analyses of the findings had revealed that the levels of miRNA were significantly reduced p<0.05 in all the three groups with the significant reduction were observed in combine group in comparison to PRP and tressfix serum alone groups. In group A the expression of all miRNA were reduced significantly p<0.05 in comparison to miRNA expression in group B and group C. In group C the expression of two miRNAs that were has-mir-941 and hsa-miRNA-212 were reduced significantly whereas the levels of remaining three miRNA remain non-significantly unaltered.   Conclusion The study give evidence of the efficacy of the intervention, which combines platelet-rich plasma (PRP) with tressfix serum, in treating seborrheic eczema. The drop in miRNA levels across all three groups suggests that the therapy had a significant influence on the underlying molecular pathways involved in skin healing and inflammation. The combination group, in comparison to the other treatment groups, showed the most significant drop in miRNA levels.  

References

Wang J, Zhang Y, Li B, Zhao Z, Huang C, Zhang X, Deng Q, Lu C, Qian H, Yang X, Sun Y. Eczema, facial erythema, and seborrheic dermatitis symptoms among young adults in China in relation to ambient air pollution, climate, and home environment. Indoor air. 2022 Jan;32(1):e12918.

Takci Z, Guler Simsek G, Uzuner H, Akbayrak A, Yıldız Seckin H, Karadag AS. Dyshidrotic eczema and seborrheic dermatitis‐like eczematous eruption following intravenous immunoglobulin therapy. Dermatologic therapy. 2020 Nov;33(6):e14147.

Sameen K. A clinical study on the efficacy of homoeopathic medicines in the treatment of Seborrhiec eczema.

Song JH, Jung MY, Kim JH, Choi JH, Park SY. A Case of Atopic Dermatitis Accompanying Seborrheic Capitis and Nummular Eczema. The Journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology. 2022;35(1):91-104.

Ahn HJ, Shin MK, Seo JK, Jeong SJ, Cho AR, Choi SH, Lew BL. Cross-sectional study of psychiatric comorbidities in patients with atopic dermatitis and nonatopic eczema, urticaria, and psoriasis. Neuropsychiatric Disease and Treatment. 2019 May 28:1469-78.

Yıldırım FE, Kabakçı C, Aksoy B. A Cross Sectional Investigation of the Effect of Eczema on Life Quality and its Comparison with Psoriasis. Journal of the Turkish Academy of Dermatology. 2022 Jan 1;16(1).

Iikura K. Development of objective method to assess the skin surface inflammation of eczema infant by digital microscope. Journal of Allergy and Clinical Immunology. 2019 Feb 1;143(2):AB131.

Ramírez‐Marín HA, Silverberg JI. Differences between pediatric and adult atopic dermatitis. Pediatric dermatology. 2022 May;39(3):345-53.

Perry M. Managing eczema in older adults: A guide for primary care nurses. Independent Nurse. 2022 Jun 2;2022(6):17-20.

Dhar S, Srinivas SM. Eczema and Dermatitis. IADVL's Concise Textbook of Dermatology. 2019 Jul 31:230.

Piquero-Casals J, Hexsel D, Mir-Bonafé JF, Rozas-Muñoz E. Topical non-pharmacological treatment for facial seborrheic dermatitis. Dermatology and therapy. 2019 Sep 1;9:469-77.

Kirsten N, Mohr N, Alhumam A, Augustin M. Prevalence and Associated Diseases of Seborrheic Skin in Adults. Clinical Epidemiology. 2021 Sep 18:845-51.

Priya V, Sathya N. Classification and prediction of dermatitis dataset using naive bayes and value weighted naive bayes algorithms. Int Res J Eng Technol. 2019;6:1077-81.

Mahlangeni GM, Tod BM, Jordaan HF, Schneider JW. Clinicopathological features of seborrheic-like dermatitis in HIV-infected adults: a single institutional descriptive cross- sectional study. The American Journal of Dermatopathology. 2021 Jan 1;43(1):27-34.

Silverberg JI, Lei D, Yousaf M, Janmohamed SR, Vakharia PP, Chopra R, Chavda R, Gabriel S, Patel KR, Singam V, Kantor R. What are the best endpoints for Eczema Area and Severity Index and Scoring Atopic Dermatitis in clinical practice? A prospective observational study. British Journal of Dermatology. 2021 May 1;184(5):888-95.

Hanifin JM, Baghoomian W, Grinich E, Leshem YA, Jacobson M, Simpson EL. The Eczema Area and Severity Index—A Practical Guide. Dermatitis. 2022 Jun 1;33(3):187-92.

Fan X, Yin Y, Dou W, Li T, Xue P, Yang Q, Ma Q. Successful treatment of corticosteroid- induced rosacea-like dermatitis with platelet-rich plasma Mesotherapy: report of seven cases. Dermatology and Therapy. 2021 Apr;11:615-23.

Mohamed AA, Attwa EM, Fawzy MM. Use of Microneedling with Platelet Rich Plasma for Management of Atrophic Post-Acne Scars. The Egyptian Journal of Hospital Medicine. 2023 Apr 1;91(1):5251-5.

Vafaei-Nodeh S, Kabiri-Abyaneh S. Long-term control of atopic dermatitis with platelet-rich plasma. JAAD Case Reports. 2021 Jan 1;7:54-6.

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Published

2024-04-21

How to Cite

1.
Rajar UDM, Fahim A, Kazi N. Effects of combine treatment of tressfix and PRP on the levels of different micro ribonucleic acids among seborrheic eczema patients. J Pak Assoc Dermatol [Internet]. 2024Apr.21 [cited 2024May22];34(2):408-14. Available from: https://jpad.com.pk/index.php/jpad/article/view/2582

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