Non langerhans cell histiocytoses in genitalia: A rare entity

Authors

  • Shiladitya Chowdhury Medical College Kolkata, West Bengal, India
  • Dyuti Das Medical College Kolkata, West Bengal, India
  • Prodip Sarkar Medical College Kolkata, West Bengal, India
  • Supratim Karmakar Medical College Kolkata, West Bengal, India
  • Partha Sarathi Nayak Medical College Kolkata, West Bengal, India
  • Ramesh Chandra Gharami Medical College Kolkata, West Bengal, India

Keywords:

Non-Langerhans cell, cyclophosphamide, immunohistochemistry

Abstract

A 35 year old man presented with multiple reddish to skin colored scrotal swellings for the last 8 to 10 months. On biopsy, well circumscribed dense nodular infiltrate composed of histiocytes, lymphocytes and stray plasma cells. On IHC: CD 68 +ve, but CD1a, S100, Langerin, BRAFV600E, CD30 were negative. Based on HPE and IHC reports, a diagnosis of non-Langerhans cell histiocytosis was made. Initially the lesions were treated with intra-lesional corticosteroids, without any significant improvement. As a newer therapy, we tried oral cyclophosphamide 50 mg BD for 2 months, followed by 50 mg OD as maintenance dose, no new lesions were noted.

References

Emile JF, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016;127(22):2672-81.

Weitzman S, Jaffe R. The non-Langerhans cell histiocytoses. Pediatr Blood Cancer. 2005;45(3):256-64.

Newman B, Hu W, Nigro K, Gilliam AC. Aggressive histiocytic disorders that can involve the skin. J Am Acad Dermatol. 2007;56(2):302-16.

doi: 10.1016/j.jaad.2006.06.010. Epub 2006 Oct 9. PMID: 17097374.

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Published

2024-07-02

How to Cite

1.
Chowdhury S, Das D, Sarkar P, Karmakar S, Nayak PS, Gharami RC. Non langerhans cell histiocytoses in genitalia: A rare entity. J Pak Assoc Dermatol [Internet]. 2024Jul.2 [cited 2024Dec.5];34(3):749-51. Available from: https://jpad.com.pk/index.php/jpad/article/view/2581

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Section

Case Reports

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