Skin Infection Treatment by using Spilanthes acmella Methanolic Extract Emulgel

Spilanthes acmella Methanolic and its Clinical Efficacy in Skin Infections

Authors

  • Aqsa Afzal Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
  • Nisar Hussain Shah Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
  • Irshad Hussain Institute of Pharmacy, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, Pakistan
  • Naveed Nisar Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
  • Romana Riaz Department of Pharmaceutics, Bakhtawar Ameen College of Pharmaceutical Sciences, Multan, Pakistan
  • Amina Riaz Department of Pharmacy, The Women University Multan, Pakistan. and School of Pharmacy, University College London, United Kingdom.
  • Javaria Saeed Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan

Keywords:

Eczema, Skin dermatitis, Skin infections, Spilanthes acmella, Plant extract, Herbal remedies

Abstract

Background Skin infections can range in severity from moderate to severe. However, skin infections can become more serious if they penetrate deeper into the skin or spread across a large portion of the body. Most skin infections are caused by specific bacteria, fungi, allergens, or other factors. Objective To examine the efficacy of an emulgel made from Spilanthes acmella extract as a herbal treatment for treating cellulitis and bacterial skin eruption. Method From May to June 2021, this randomized controlled trial was carried out at a neighborhood clinic in Multan. Three patients in total took part in the study, and each one received an emulgel based on Spilanthes acmella that contained 2% pure extract. For a total of 14 days, each patient applied emulgel three times each day to the suffering area. Each patient had pictures taken on the 0th, 7th, and 14th days. Results All patients' skin infections had greatly improved after 14 days, as seen in the post-14-days figures. The eczematous conditions got better the skin softer, and every one of lesions and skin eruptions had cleared out. Conclusion It has been determined that the S extract base emulgel demonstrated strong anti-inflammatory, anti-fungal, and anti-bacterial activity to treat many kinds of infectious and eczematous skin disorders. Due to the formulation's emollient effect, which lasted between 7 and 14 days, the skin became normal and smooth.

References

Al-Qudah, T. S., U. Zahra, R. Rehman, M. I. Majeed, S. Sadique, S. Nisar, R. Tahtamouni and R. W. Tahtamouni. Lemon as a source of functional and medicinal ingredient: A review. Int J Chem Biochem Sci. 2018;14: 55-61.

Bernard, P. Management of common bacterial infections of the skin. Curr Opin Infect Dis. 2008;21(2):122-8.

Bradley, J.-C., M. H. Abraham, W. E. Acree and A. S. Lang. Predicting Abraham model solvent coefficients. Chem Cen J. 2015;9(1): 1-10.

Chakraborty, A., R. K. Devi, S. Rita, K. Sharatchandra and T. I. Singh. Preliminary studies on antiinflammatory and analgesic activities of Spilanthes acmella in experimental animal models. Indian J Pharmacol. 2004;36(3):148.

Chovanová, R., M. Mikulášová and Š. Vaverková. In vitro antibacterial and antibiotic resistance modifying effect of bioactive plant extracts on methicillin-resistant Staphylococcus epidermidis. Int J Microbiol. 2013.

Dahanukar, S., R. Kulkarni and N. Rege . Pharmacology of medicinal plants and natural products. Indian J Pharmacol. 2000;32(4):S81-S118.

Dubey, S., S. Maity, M. Singh, S. A. Saraf and S. Saha. Phytochemistry, pharmacology and toxicology of Spilanthes acmella: a review. Adv Pharmacol Sci. 2013.

Hossan, S., B. Agarwala, S. Sarwar, M. Karim, R. Jahan and M. Rahmatullah. Traditional use of medicinal plants in Bangladesh to treat urinary tract infections and sexually transmitted diseases. Ethnobot Res App. 2010;8:61-74.

Kadir, H. A., M. B. Zakaria, A. A. Kechil and M. D. Azirun. Toxicity and electrophysiological effects of Spilanthes amella Murr. extracts on Periplaneta americana L. Pesticide Science. 1989;25(4): 329-35.

Kawaii, S., Y. Tomono, E. Katase, K. Ogawa, M. Yano, M. Koizumi, C. Ito and H. Furukawa. Quantitative study of flavonoids in leaves of Citrus plants. J Agricul Food Chem. 2000;48(9):3865-71.

Rani, S. and S. Murty. Antifungal potential of flower head extract of Spilanthes acmella Linn. African J Biomed Res. 2006;9(1).

RaoT, M., G. RaoB and V. RaoY. Anti-Bacterial Activity of Different extracts of Melochia corchorifolia and Spilanthes acmellaaerial parts. J Pharm Res. 2012; 5(6):3022-4.

Rodov, V., S. Ben-Yehoshua, D. Q. Fang, J. J. Kim and R. Ashkenazi. Preformed antifungal compounds of lemon fruit: citral and its relation to disease resistance. J Agricult Food Chem. 1995;43(4):1057-61.

Saritha, K., E. Prakash, N. Ramamurthy and C. Naidu. Micropropagation of Spilanthes acmella Murr. Biologia Plantarum. 2002; 45(4):581-4.

Shukr, M. and G. F. Metwally. Evaluation of topical gel bases formulated with various essential oils for antibacterial activity against methicillin-resistant Staphylococcus aureus. Trop J Pharm Res. 2013;12(6):877-84.

Tabassum, N. and M. Hamdani. Plants used to treat skin diseases. Pharmacognosy Rev. 2014;8(15):52.

Tranchida, P. Q., I. Bonaccorsi, P. Dugo, L. Mondello and G. Dugo. Analysis of Citrus essential oils: state of the art and future perspectives. A review. Flav Fragr J. 2012; 27(2): 98-123.

Downloads

Published

2024-05-06

How to Cite

1.
Afzal A, Shah NH, Hussain I, Nisar N, Riaz R, Riaz A, Saeed J. Skin Infection Treatment by using Spilanthes acmella Methanolic Extract Emulgel: Spilanthes acmella Methanolic and its Clinical Efficacy in Skin Infections . J Pak Assoc Dermatol [Internet]. 2024May6 [cited 2024May19];34(1):130-3. Available from: https://jpad.com.pk/index.php/jpad/article/view/2473

Issue

Section

Original Articles