Exploring novel therapeutics targets for psoriasis: Insights into pathogenesis and drug development


  • Ambreen Siddique PhD Scholar
  • Fiaz-ud-Din Ahmad Department of Pharmacology, Islamia University Bahawalpur.
  • Uzair Ahmed Qureshi Department of Medicine and Allied Health Sciences, Islamia University Bahawalpur.


Therapeutic, Psoriasis, Pathogenesis


Objective This research aimed to explore and identify novel therapeutic targets for psoriasis, elucidate the underlying pathogenic mechanisms, and develop innovative drug candidates or repurpose existing drugs for effective treatment.   Methods A comprehensive literature review was conducted to gather current knowledge on psoriasis pathogenesis and existing treatment modalities. Various molecular targets involved in key cellular processes, signaling pathways, and immune dysregulation were identified and evaluated as potential therapeutic targets. In vitro experiments using human skin cell cultures and animal models were employed to assess the efficacy, safety, and mechanism of action of developed drug candidates or repurposed drugs. Pharmacological evaluations, including bioavailability and pharmacokinetic studies, were performed to determine their potential for clinical translation.   Results The study identified several promising therapeutic targets implicated in the pathogenesis of psoriasis, including specific cytokines, immune cell subsets, and signaling pathways. Experimental findings demonstrated the efficacy of newly developed drug candidates or repurposed drugs in suppressing keratinocyte hyper proliferation, mitigating inflammation, and modulating immune responses. Pharmacological evaluations indicated favorable drug properties, including suitable bioavailability and pharmacokinetic profiles.   Conclusion The research findings provide valuable insights into the pathogenesis of psoriasis and potential therapeutic targets for intervention. The identification and development of novel drug candidates or repurposing existing drugs targeting these therapeutic targets hold promise for improved treatment outcomes in psoriasis patients. Further translational research and clinical trials are warranted to validate these findings and establish their clinical efficacy and safety. The interdisciplinary approach merging pharmacology and dermatology in this study showcases the importance of collaboration and highlights the potential for developing personalized treatment strategies for psoriasis patients.  


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How to Cite

Siddique A, Ahmad F- ud-D, Qureshi UA. Exploring novel therapeutics targets for psoriasis: Insights into pathogenesis and drug development. J Pak Assoc Dermatol [Internet]. 2023Oct.12 [cited 2023Nov.28];33(4):1249-56. Available from: https://jpad.com.pk/index.php/jpad/article/view/2468



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