Correlation between the Severity and Type of Acne Vulgaris Lesions with Serum Vitamin D Levels
Correlation between the Severity and Type of Acne Vulgaris Lesions with Serum Vitamin D Levels: A cases control study of HIT Hospital, Taxila
Keywords:
Acne Vulgaris, Vitamin D, GAG scoreAbstract
Back ground: Vitamin D plays a crucial role in various physiological processes, including immune regulation, inflammation, and sebaceous gland function, all of which are relevant to acne pathogenesis. Objective: To determine association between Severity and Type of Acne Lesions with Serum Vitamin D Levels Material and Method: This case control study included 162 unmarried females of 12-30 years of age entitled to HIT hospital treatment were enrolled through random sampling technique, out of which 71 females with acne were taken as cases and 91 matching healthy controls were enrolled. History of vitamin supplementation in the last 6 months, acne treatment, systemic steroids or any chronic inflammatory disease were not included. GAG score was used to grade the acne and Vit D levels were sorted as deficient (<30 nmol/L), inadequate (30-75nmol/L) and adequate (>75nmol/L). The data was entered and analyzed using SPSS-28. t-test was used for comparing Vitamin D levels among cases and controls. To correlate the sub groups of acne and vitamin D among cases and controls, chi square test was performed, p-value, when <0.05 was considered statistically significant. Results: Mean age of participants with acne vulgaris was 19.23± 7.42 while the mean age of controls was 21.4± 6.97. Statistically significant association was found between mean vitamin D levels among cases and controls (p-value = 0.024). Moreover, a statistically significant relation was found between acne vulgaris severity and vitamin D levels (p-value= 0.047) Conclusion: This study showed Vitamin D deficiency is evident in acne vulgaris patients and a statistically significant association with the severity of acne lesions. Keywords: Acne Vulgaris, Vitamin D, GAG scoreReferences
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