Frequency of Dyslipidaemia among Patients of Lichen Planus presenting to Tertiary care setting

Authors

  • Alina Abbas Department of Dermatology, AIMC/ Jinnah Hospital, Lahore
  • Aneela Gillani Department of Dermatology, AIMC/ Jinnah Hospital, Lahore
  • Hira Tariq Department of Dermatology, Services Institute of Medical Sciences, Lahore
  • Aqsa Zubair Department of Dermatology, AIMC/ Jinnah Hospital, Lahore
  • Areesha Fatima Department of Dermatology, AIMC/ Jinnah Hospital, Lahore
  • Tariq Rashid
  • Sana Aslam Department of Dermatology, AIMC/ Jinnah Hospital, Lahore

Keywords:

Frequency, lichen planus

Abstract

Background   Lichen planus (LP) is a chronic inflammatory disorder that affects skin and/or mucous membranes. It is a T-cell-mediated inflammatory disorder which causes lipid metabolic aberrations and is associated with increased risk of cardiovascular diseases.  Objective. To determine the frequency of dyslipidemia among patients of lichen planus presenting to the Dermatology Department of a tertiary care hospital.  Methods   In this cross sectional study, 80 cases of lichen planus were included after clinical and histopathological confirmation. Presence or absence of dyslipidemia was confirmed by fasting lipid profile. Patients taking lipid lowering drugs, patients of diabetes, hypothyroidism (TSH > 4.2 mIU/ml), hypertension or ischemic heart disease, patients with BMI more than 30 kg/m2, patients with family history of dyslipidemia and early cardiac death, were excluded. Stratification of dyslipidemia with regards to age, gender and area of involvement was carried out. Results   There were 47 males (58.8%) and 33 females (41.2%). Mean age of the patients was 39.00±11.76 years. Cutaneous lichen planus was seen in 32 (40%) patients, mucosal in 28 (35%) patients and both (cutaneous and mucosal) in 20 (25%) patients. Dyslipidemia was present in 48 (60%) patients. Stratification of dyslipidemia with regard to age and gender was not significant but with regard to mucosal and cutaneous involvement was significant. Conclusion  Lichen planus is significantly related to dyslipidemia according to this study. Therefore meticulous screening for dyslipidemia is needed in patients of LP. Key words   Frequency, lichen planus, dyslipidemia.      

References

Tziotzios C, Lee J.Y.W, Brier T, Saito R, Hsu C.K, Bhargava K, Stefanato C.M, Fenton D.A, McGrath J.A. Lichen planus and lichenoid dermatoses: Clinical overview and molecular basis. J Am Acad Dermatol. 2018;79(5):789–804.

Okpala I.C, Akinboro A.O, Ezejoifor I.O, Onunu A.N, Okwara B.U. Metabolic Syndrome and Dyslipidemia among Nigerians with Lichen Planus: A Cross-Sectional Study. Indian J Dermatol. 2019;64(4):303–10.

González-Moles M.Á, Warnakulasuriya S, González-Ruiz I, González-Ruiz L, Ayén Á, Lenouvel D, Ruiz-Ávila I, Ramos-García P. Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis. Oral Dis. 2021;27(4):813–28.

Özkur E, U˘gurer E, Altunay I.K. Dyslipidemia in Lichen Planus: A Case-control Study. Med Bull Sisli Etfal Hastan Tip Bul. 2020;54(1):62–6.

Husein-ElAhmed H, Gieler U, Steinhoff M. Lichen planus: A comprehensive evidence-based analysis of medical treatment. J Eur Acad Dermatol Venereol. 2019;33(10):1847–62.

Saleh N, Samir N, Megahed H, Farid E. Homocysteine and other cardiovascular risk factors in patients with lichen planus. J Eur Acad Dermatol Venereol. 2014; 28(11):1507-13.

Singla R, Ashwini P.K, Jayadev B. Lichen Planus and Metabolic Syndrome: Is There a Relation? Indian Dermatol Online J. 2019;10(5):555–9.

Hashba H, Bifi J, Thyvalappil A, Sridharan R, Sreenivasan A, Mathew P. Prevalence of Metabolic Syndrome in Patients with Lichen Planus: A Cross-sectional Study from a Tertiary Care Center. Indian Dermatol Online J. 2018;9(5):304–8.

Hasan S, Ahmed S, Kiran R, Panigrahi R, Thachil J.M, Saeed S. Oral lichen planus and associated comorbidities: An approach to holistic health. J Fam Med Prim Care. 2019;8(3):3504–17.

Dreiher J, Shapiro J, Cohen AD. Lichen planus and dyslipidaemia: A case‑control study. Br J Dermatol. 2009;161:626‑9.

López‑Jornet P, Camacho‑Alonso F, Rodríguez‑Martínes MA. Alterations in serum lipid profile patterns in oral lichen planus: A cross‑sectional study. Am J Clin Dermatol. 2012;13:399‑404.

Gupta S, Gupta S. Alterations in serum lipid profile patterns in oral cancer and oral precancerous lesions and conditions – A clinical study. Indian J Dent. 2011;2:1‑7.

Arshad Z , Sanai M, Nusrat W, Asghar MN, Ghias A, Arshad A.Frequency of dyslipidemia in patients with lichen planus. J Pak Assoc Dermatol. 2021;31(4):643-6.

Khan S, Pirzado MS, Kalhoro HBA, Rajper N, Memon SM, Memon FH. Frequency of Dyslipidemia in Patients with Lichen Planus: A Comparative Cross-Sectional Study. J Liaquat Uni Med Health Sci. 2022;21(02):121-5.

Azeez N, Asokan N. Association of lichen planus with dyslipidemia: A comparative, cross-sectional study. Clin Dermatol Rev. 2019;3:68-71.

Nasiri S, Sadeghzadeh-Bazargan A, Robati RM, Haghighatkhah HR, Younespour S. subclinical atherosclerosis and cardiovascular markers in patients with lichen planus: A case-control study. Indian J Dermatol Venerol Leprol. 2019;85:138-44.

Kumar SA, Krishnam Raju PV, Gopal KVT, Rao TN. Comorbidities in Lichen Planus: A Case-control Study in Indian Patients. Indian Dermatol Online J. 2019;10(1):34-7.

Downloads

Published

2024-05-06

How to Cite

1.
Alina Abbas, Aneela Gillani, Hira Tariq, Zubair A, Fatima A, Rashid T, Aslam S. Frequency of Dyslipidaemia among Patients of Lichen Planus presenting to Tertiary care setting. J Pak Assoc Dermatol [Internet]. 2024May6 [cited 2024May22];34(1):141-5. Available from: https://jpad.com.pk/index.php/jpad/article/view/2451

Issue

Section

Original Articles

Most read articles by the same author(s)

1 2 3 4 > >>