Correlation between the disease severity and serum levels of c reactive protein, erythrocyte sedimentation rate and ferritin in patients with chronic spontaneous urticaria: A cross-sectional study

Authors

  • Kalegowda Deepadarshan Department of Dermatology, Mandya Institute of Medical Sciences, Mandya/ Rajiv Gandhi University of Medical Sciences, Bengaluru, Karnataka, India.
  • Harish M R Rajiv Gandhi University of Medical Sciences
  • Shashikumar B M RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
  • Hemavathy B K RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

Keywords:

Chronic spontaneous urticaria, ESR, CRP, Ferritin

Abstract

ABSTRACT:   Background: Chronic spontaneous urticaria, or CSU, is the recurrence of persistent, recurrent wheals, angioedema, or both for more than six weeks due to known or unidentified causes. C reactive protein (CRP) levels can be measured to assess disease activity, prognosis, and therapy effectiveness. CRP testing is advised for all patients with chronic urticaria, according to the most recent EAACI/GA2LEN/EDF/WAO guidelines.   Methods: For the study, 76 patients with a clinical diagnosis of persistent spontaneous urticaria were enrolled.  The levels of serum ferritin, ESR, and CRP were calculated. The urticaria activity score (UAS 7) was used to gauge the severity of the disease. The Dermatology Life Quality Index was used to evaluate quality of life at the time of blood sample.   Results: The mean CRP level was 0.8 mg/L, and 36.84% of patients had increased CRP levels. Of the patients, 34.21% had elevated ESR. When comparing CRP and UAS7, the Pearson correlation value was 0.5, showing a moderately positive association, and when comparing ESR and UAS7, it was 0.1, showing a very weak positive correlation. DLQI was on average 7.5.    Conclusion: Elevated CRP is linked to increased disease activity, and measuring this activity can help manage patients with CSU more effectively.   KEY WORDS: Chronic spontaneous urticaria, CRP, ESR, ferritin.

Author Biographies

Kalegowda Deepadarshan, Department of Dermatology, Mandya Institute of Medical Sciences, Mandya/ Rajiv Gandhi University of Medical Sciences, Bengaluru, Karnataka, India.

ASSISTANT PROFESSOR, DEPARTMENTOF DERMATOLOGY,  

Harish M R, Rajiv Gandhi University of Medical Sciences

PROFESSOR, DEPARTMENT OF DERMATOLOGY, MANDYA INSTITUTE  OF MEDICAL SCIENCES, MANDYA.

Shashikumar B M, RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

ASSOCIATE PROFESSOR, DEPARTMENT OF DERMATOLOGY, MANDYA INSTITUTE  OF MEDICAL SCIENCES, MANDYA.

Hemavathy B K, RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

JUNIOR RESIDENT DEPARTMENT OF DERMATOLOGY, MANDYA INSTITUTE  OF MEDICAL SCIENCES, MANDYA.

References

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Published

2024-05-06

How to Cite

1.
Deepadarshan K, Harish M R, Shashikumar B M, Hemavathy B K. Correlation between the disease severity and serum levels of c reactive protein, erythrocyte sedimentation rate and ferritin in patients with chronic spontaneous urticaria: A cross-sectional study. J Pak Assoc Dermatol [Internet]. 2024May6 [cited 2024May22];34(1):171-7. Available from: https://jpad.com.pk/index.php/jpad/article/view/2428

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