Correlation between the disease severity and serum levels of c reactive protein, erythrocyte sedimentation rate and ferritin in patients with chronic spontaneous urticaria: A cross-sectional study

Authors

  • Kalegowda Deepadarshan Department of Dermatology, Mandya Institute of Medical Sciences, Mandya/ Rajiv Gandhi University of Medical Sciences, Bengaluru, Karnataka, India.
  • Harish M R Rajiv Gandhi University of Medical Sciences
  • Shashikumar B M RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
  • Hemavathy B K RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

Keywords:

Chronic spontaneous urticaria, ESR, CRP, Ferritin

Abstract

Background Chronic spontaneous urticaria, or CSU, is the recurrence of persistent, recurrent wheals, angioedema, or both for more than six weeks due to known or unidentified causes. C reactive protein (CRP) levels can be measured to assess disease activity, prognosis, and therapy effectiveness. CRP testing is advised for all patients with chronic urticaria, according to the most recent EAACI/GA2LEN/EDF/WAO guidelines.   Methods For this study, 76 patients with a clinical diagnosis of persistent spontaneous urticaria were enrolled.  The levels of serum ferritin, ESR, and CRP were calculated. The urticaria activity score (UAS 7) was used to gauge the severity of the disease. The Dermatology Life Quality Index was used to evaluate quality of life at the time of blood sample.   Results The mean CRP level was 0.8 mg/L, and 36.84% of patients had increased CRP levels. Of the patients, 34.21% had elevated ESR. When comparing CRP and UAS7, the Pearson correlation value was 0.5, showing a moderately positive association. When comparing ESR and UAS7, it was 0.1, showing a very weak positive correlation. DLQI on average was 7.5.   Conclusion Elevated CRP is linked to increased disease activity, and measuring this activity can help manage patients with CSU more effectively.  

Author Biographies

Kalegowda Deepadarshan, Department of Dermatology, Mandya Institute of Medical Sciences, Mandya/ Rajiv Gandhi University of Medical Sciences, Bengaluru, Karnataka, India.

ASSISTANT PROFESSOR, DEPARTMENTOF DERMATOLOGY,  

Harish M R, Rajiv Gandhi University of Medical Sciences

PROFESSOR, DEPARTMENT OF DERMATOLOGY, MANDYA INSTITUTE  OF MEDICAL SCIENCES, MANDYA.

Shashikumar B M, RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

ASSOCIATE PROFESSOR, DEPARTMENT OF DERMATOLOGY, MANDYA INSTITUTE  OF MEDICAL SCIENCES, MANDYA.

Hemavathy B K, RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

JUNIOR RESIDENT DEPARTMENT OF DERMATOLOGY, MANDYA INSTITUTE  OF MEDICAL SCIENCES, MANDYA.

References

REFERENCES:

Hon KL, Leung AKC, Ng WGG, Loo SK. Chronic urticaria: An overview of treatment and recent patents. Recent Pat Inflamm Allergy Drug Discovery. 2019;13(1):27-37.

Balp MM, Vietri J, Tian H, Isherwood G. The Impact of Chronic Urticaria from Patient’s perspective: A survey in five European Countries. 2015;8(6):551-8.

Kolkhir P, Altrichter S, Hawro T, Maurer M. C-reactive protein is linked to disease activity, impact, and response to treatment in patients with chronic spontaneous urticaria. Allergy. 2018;73(4):940-8.

Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI)-a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994;19(3):210-6.

Hollis K, Proctor C, McBride D, Balp MM, McLeod L, Hunter S, et al. Comparison of Urticaria Activity Score Over 7 Days (UAS7) Values Obtained from Once-Daily and Twice-Daily Versions: Results from the ASSURE-CSU Study. Am J Clin Dermatol. 2018;19(2):267-74.

Sachdeva S, Gupta V, Amin SS, Tahseen M. Chronic urticaria. Indian J Dermatol. 2011;56(6):622-8.

Grzanka A, Damasiewicz-Bodzek A, Kasperska-Zajac A. The relationship between circulating concentrations of interleukin 17 and C reactive protein in chronic spontaneous urticaria. Allergy Asthma Clin Immunol. 2017;13:25.

Czarnecka Operacz M, Joanna Szulczynska Gabor J, Lesniewska K, Teresiak Mikolajczak E, Bartkiewicz P, et al. Acute phase response and its biomarkers in acute and chronic urticaria. Adv Dermatol Allergol. 2018;35(4):400-7.

Mlynek A, Zalewska-Janowska A, Martus P, Staubach P, Zuberbier T, Maurer M. How to assess disease activity in patients with chronic urticaria? Allergy. 2008;63:777-80.

Criado RF, Bensi CG, Criado PR, Henriques MT, Espindola BAR, Machado Filho CD. Evaluation of serum levels of C reactive protein, D dimer and Autologous Serum Skin test in patients with chronic spontaneous urticaria in a Brazilian tertiary centre: A cross sectional study. An Bras Dermatol. 2021;96:148-54.

Sproston NR, Ashworth JJ. Role of C- Reactive Protein at sites of inflammation and infection. Front Immunol. 2018;9:754.

Faraschian M, Ansar A, Sobhan M, Hoseinpoor V. C-reactive protein serum level in patients with psoriasis before and after treatment with narrow-band ultraviolet B. An Bras Dermatol. 2016;91:580-3.

Puxeddu I, Petrelli F, Angelotti F, Croia C, Migliorini P. Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications. J Asthma Allergy. 2019; 12:285-95.

Aleem S, Masood Q, Hassan I. Correlation of C-reactive protein levels with severity of chronic urticaria. Indian J Dermatol. 2014;59(6):636.

Downloads

Published

2024-05-06

How to Cite

1.
Deepadarshan K, Harish M R, Shashikumar B M, Hemavathy B K. Correlation between the disease severity and serum levels of c reactive protein, erythrocyte sedimentation rate and ferritin in patients with chronic spontaneous urticaria: A cross-sectional study. J Pak Assoc Dermatol [Internet]. 2024May6 [cited 2025Jan.20];34(1):171-7. Available from: https://jpad.com.pk/index.php/jpad/article/view/2428

Issue

Section

Original Articles