Correlation between the disease severity and serum levels of c reactive protein, erythrocyte sedimentation rate and ferritin in patients with chronic spontaneous urticaria: A cross-sectional study

Abstract

Background Chronic spontaneous urticaria, or CSU, is the recurrence of persistent, recurrent wheals, angioedema, or both for more than six weeks due to known or unidentified causes. C reactive protein (CRP) levels can be measured to assess disease activity, prognosis, and therapy effectiveness. CRP testing is advised for all patients with chronic urticaria, according to the most recent EAACI/GA2LEN/EDF/WAO guidelines.   Methods For this study, 76 patients with a clinical diagnosis of persistent spontaneous urticaria were enrolled.  The levels of serum ferritin, ESR, and CRP were calculated. The urticaria activity score (UAS 7) was used to gauge the severity of the disease. The Dermatology Life Quality Index was used to evaluate quality of life at the time of blood sample.   Results The mean CRP level was 0.8 mg/L, and 36.84% of patients had increased CRP levels. Of the patients, 34.21% had elevated ESR. When comparing CRP and UAS7, the Pearson correlation value was 0.5, showing a moderately positive association. When comparing ESR and UAS7, it was 0.1, showing a very weak positive correlation. DLQI on average was 7.5.   Conclusion Elevated CRP is linked to increased disease activity, and measuring this activity can help manage patients with CSU more effectively.