Comparative efficacy of topical calcipotriol and tacrolimus in Alopecia Areata. A prospective trial

vitamin D analogues in alopecia areata


  • Muhammad Fahim Tehsil headquarters hospital takhtbhai ,mardan
  • Hina Khoso Ex trainee medical officer, Department of Dermatology Shaheed mohtarama Benazir Bhutto medical university, Larkana sindh
  • Jahangir Khan Department of Dermatology, AL ADAN Hospital, Kuwait.
  • Rabeeka Bakhtiar Department of Dermatology, Medical Teaching Institution Hayatabad, Peshawar


Alopecia areata, Calcipotriol, SALT score, Tacrolimus


Introduction: Alopecia areata (AA) is a non-scarring, inflammatory type of hair loss., ranging in severity from patchy hair loss to alopecia totalis and universalis. Various treatment modalities are available for alopecia areata, including topical, intralesional, and systemic steroids, minoxidil, and systemic immunosuppressives. Multiple studies demonstrated the variable efficacy of vitamin D analogs in alopecia areata, but none have compared them with topical tacrolimus. Study Station: Tehsil Headquarters Hospital TakhtBhai, Mardan Materials and Methods: It was a randomized control trial. A total of 80 patients were enrolled in the study, 40 in each group. Using the technique of consecutive non-probability sampling, patients were separated into groups A and B. Group A received topical calcipotriol (0.005%), while group B patients were treated with tacrolimus (0.1%). Both drugs were used twice a day for 6 months. Lesions are examined every month, and at the end of 6 months, a final SALT score is calculated. Results: In our study, group A had 52% males and 48% females, while group B had 49% males and 51% females. The mean age was 32.6±6.7&31.5± 7.4 in Group A&B respectively. The mean baseline SALT score in group A was 14.3±5.2 while in group B was13±5.1. On the other hand, the mean SALT score after 6 months was 6.2±2.3 in Group A and 6.2±2.3in Group B. The efficacy in Group A came out to be 67%, while in Group B 33% efficacy was noted (p-value=0.0132) Conclusion: This study found that topical calcipotriol is superior to topical tacrolimus for hair growth in patients with alopecia areata. The difference was statistically significant. Keywords: Alopecia areata, Calcipotriol, SALT score, Tacrolimus


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Fahim M, Khoso H, Khan J, Bakhtiar R. Comparative efficacy of topical calcipotriol and tacrolimus in Alopecia Areata. A prospective trial: vitamin D analogues in alopecia areata. J Pak Assoc Dermatol [Internet]. 2024May6 [cited 2024May19];34(1):98-105. Available from:



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