The Evaluation of Serum Vitamin D Levels In Patients Having Chronic Plaque Psoriasis

Abstract

Background Psoriasis is chronic inflammatory disease having prevalence of 3 % in developed world. Most of these patients have low levels of serum vitamin D. Objective To determine vitamin D levels  in serum of  patients having  chronic plaque psoriasis. Methods In this cross sectional study 400 patients who fulfilled the selection criteria were enrolled from Dermatology Department Mayo Hospital Lahore over 6 months (June 6, 2018 –December 6, 2018). Informed consent was taken. Demographic profile was noted. Their blood samples were taken after aseptic measures and sent to hospital laboratory for analysis of Vitamin D levels by ELISA method. The levels of Vitamin D3 were labeled as; Deficient (<20ng/ml), Insufficient (20ng /ml-30ng/ml), Desirable (>30ng/ml). Results The mean age of patients was 30.20 ± 5.81 years with range of 18-40 years. 177(44.2%) cases were 18-29 years old and 223(55.8%) cases were 30-40 years of age. There were 166(41.5%) males and 234(58.5%) cases were female. A total of 168(42%) cases had disease duration 6- >12 months and 232(58%) cases had disease duration > 12 months. A total of 118(29.5%) cases had mild, 183 (45.75%) cases had moderate and 99 (24.75%) cases had severe disease. There were 69(17.2%) cases that had desirable vitamin D levels, 135(33.8%) cases had vitamin D deficiency while 196 (49%) cases had insufficient vitamin D levels. Conclusion Findings of this study concludes that only 17.2% patients had desirable vitamin D levels while rest of the 82.8% cases had low levels of vitamin D levels. Hence, while treating patients with psoriasis, treatment of Vitamin D deficiency must also be considered.Keywords Psoriasis, Vitamin D, Vitamin D deficiency, inadequate levels.