Allogeneic mesenchymal stem cells therapy for burn wound rat model: A systematic review and meta-analysis

Authors

  • Maureen Miracle Stella Medical Profession Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • Kenny Wijaya Sutanto Medical Profession Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • Kevin Tandarto Medical Profession Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • Ignatius Ivan Medical Profession Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • Fanny Budiman Medical Profession Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • Veronika Maria Sidharta Department of Histology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • Lorettha Wijaya Department of Dermatology and Venereology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Keywords:

allogeneic, mesenchymal, stem cells, burn, rat

Abstract

Background: Burn wounds are a burdensome problem affecting many people and cause high morbidity and mortality. Therefore, a more effective burn wound treatment is urgently needed. Objective: To evaluate the allogeneic mesenchymal stem cells’ efficacy in treating burn wounds in rats. Method: English articles were collected from the following databases: ProQuest, PubMed, EBSCOhost, SAGE, JSTOR, GARUDA, and Open Gray (January 1st, 2011, to March 29th, 2020). The inclusion criteria are original articles, rat burns experimental models, stem cells therapy using MSCs for experimental groups, non-functional solution, excipient or no treatment for control group, and healing rate of the burn wounds as the main outcome. Results and discussion: We found 9 articles in English. Hot plates or radiation were used to create burn model in 170 rats. The burn wounds degree ranged from partial (n = 2) to full-thickness (n = 4). Around 0.1–3.2 million stem cells were administered through various routes. The wound re-epithelialization rate was analyzed statistically and is shown more significant in the treatment group. Conclusion: Allogeneic MSCs may have benefits for treating burn wounds, although more experiments are still needed. RCTs are recommended to evaluate the efficacy and adverse effects of the MSCs treatment. Keywords: allogeneic; mesenchymal; stem cells; burn; rat

Author Biographies

Maureen Miracle Stella, Medical Profession Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Doctor of Medicine, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Kenny Wijaya Sutanto, Medical Profession Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Medical Profession Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Kevin Tandarto, Medical Profession Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Doctor of Medicine, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Ignatius Ivan, Medical Profession Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Doctor of Medicine, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Fanny Budiman, Medical Profession Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Doctor of Medicine, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Veronika Maria Sidharta, Department of Histology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Department of Histology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Lorettha Wijaya, Department of Dermatology and Venereology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Department of Dermatology and Venereology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

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Published

2023-10-12

How to Cite

1.
Stella MM, Sutanto KW, Tandarto K, Ignatius Ivan, Budiman F, Sidharta VM, Wijaya L. Allogeneic mesenchymal stem cells therapy for burn wound rat model: A systematic review and meta-analysis. J Pak Assoc Dermatol [Internet]. 2023Oct.12 [cited 2024Dec.5];33(4):1645-59. Available from: https://jpad.com.pk/index.php/jpad/article/view/2354

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Review Articles