Intradermal vs Micro-needling Platelet-Rich Plasma Treatment for Atrophic Acne Scars in Fitzpatrick Skin Type 5 Subjects: Two Case Reports


  • Ketut Alit Pinidha Savitri
  • Widya Widita Hasanuddin University
  • Asnawi Madjid


Acne scar, Atrophic scar, Platelet-rich plasma, Intradermal, Micro-needling, platelet rich plasma, acne scars, topical vitamin C


Introduction Atrophic scars are the most common and frequent complication of acne. The use of platelet-rich plasma (PRP) through the release of growth factors, cytokines and chemokines from α-granules may aid in the treatment of such atrophic scars.   Objective To compare the effectiveness of intradermal administration of PRP with topical administration using micro-needling for treatment of atrophic acne scars.   Methods Two subjects with atrophic scars were selected. Procedures were performed three times for the first subject and two times for the second subject with an interval of 3 weeks. The right side of the face was treated using intradermal PRP, while the left side was treated using micro-needling PRP. Assessments of clinical improvement were obtained by evaluating the photos of each treatment and assessment of the severity of the scar used the Global Acne Scarring Grading System and Lipper & Perez Score.   Results Facial area treated using intradermal PRP in the first patient experienced an 85.71% improvement in Global Acne Scarring Grading System and 68.59% improvement in Lipper & Perez score after 9 weeks of treatment, while the second patient experienced 64.28% improvement in Global Acne Scarring Grading System and 71.35% improvement in Lipper & Perez score after 6 weeks of treatment. Furthermore, the first patient treated with micro-needling experienced 53.33% improvement in Global Acne Scarring Grading System along with 62.71% improvement in Lipper & Perez Score after 9 weeks of treatment. While the second patient experienced 61.90% improvement in Global Acne Scarring Grading System and 58.65% improvement in Lipper and Perez Score after 6 weeks of treatment.   Conclusion Intradermal administration of PRP is more effective compared to topical administration using micro-needling, especially for boxcars and rolling scars. However, with notably more complications such as edema, pain, and longer downtime.  


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How to Cite

Savitri KAP, Widita W, Madjid A. Intradermal vs Micro-needling Platelet-Rich Plasma Treatment for Atrophic Acne Scars in Fitzpatrick Skin Type 5 Subjects: Two Case Reports . J Pak Assoc Dermatol [Internet]. 2024May6 [cited 2024May19];34(1):322-7. Available from:



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