Analysis of vitamin E in leprosy patients

Authors

  • Cut Putri Hazlianda Departmen of Dermatology and Venereology, Universitas Sumatera Utara
  • Dina Arwina Dalimunthe Department of Dermatology and Venereology, Universitas Sumatera Utara
  • Donna Partogi Department of Dermatology and Venereology, Universitas Sumatera Utara

Keywords:

Vitamin E, Leprosy

Abstract

Background  Mycobacterium leprae is the primary causative agent of the chronic infectious illness leprosy, can affect peripheral nerves and the skin. Vitamin E, a fat-soluble antioxidant, is essential in the body and can modulate various immune responses. Previous study showed reduced vitamin E levels in leprosy patients. This study evaluated vitamin E levels, differences in paucibacillary and multibacillary type leprosy subjects, and the correlation between bacterial index and vitamin E levels.   Methods In this study, 24 leprosy subjects have been included in this analytical investigation using a cross-sectional methodology. Between March and October 2018, the study was carried out in the Dermatology and Venerology Department of the Leprosy Division at the Haji Adam Malik General Hospital in Medan, Pirngadi General Hospital in Medan, Belidahan Leprosy Hospital, Sicanang Leprosy Hospital, and Lau Simomo Leprosy Hospital.   Results Leprosy was found primarily in males (70.8%), 16–35 years old (50%). The mean value of vitamin E levels in MB leprosy (9.62±3.91 mg/L) was lower than in PB leprosy (10.55±2.12 mg/L). This study showed a statistically significant correlation between bacterial index and vitamin E levels (r=0.284, p=0.043).   Conclusion There is a correlation between bacterial index and vitamin E levels.  

References

Sarode G, Sarode S, Anand R, Patil S, Jafer M, Baeshen H, et al. Epidemiological aspects of leprosy. Disease-a-Month. 2020;66(7).

Ribeiro MDA, Silva JCA, Oliveira SB, Organization WH, Normas SA, Ministério da Saúde B, et al. Guidelines for the diagnosis, treatment, and prevention of leprosy. World Heal Organ. 2020;Jan(2):1–7.

Wagenaar I, van Muiden L, Alam K, Bowers R, Hossain MA, Kispotta K, et al. Diet-Related Risk Factors for Leprosy: A Case-Control Study. PLoS Negl Trop Dis. 2015;9(5):1–16.

Trimbake S, Sontakke A, Dhat V. Oxidative stress and antioxidant vitamins in leprosy. Int J Res Med Sci. 2013;1(3):1.

Khalid HN, Mostafa MI, Attia NS, Bazid HASE. Serum level of Selenium, Zinc, and Vitamin C and their relation to the clinical spectrum of leprosy. J Infect Dev Ctries. 2022;16(3):491–9.

Dwivedi VP, Banerjee A, Das I, Saha A, Dutta M, Bhardwaj B, et al. Diet and nutrition: An important risk factor in leprosy. Microb Pathog. 2019;137:103714. Available from: https://doi.org/10.1016/j.micpath.2019.103714

Vázquez CMP, Netto RSM, Barbosa KBF, de Moura TR, de Almeida RP, Duthie MS, et al. Micronutrients influencing the immune response in leprosy. Nutr Hosp. 2014;29(1):26–36.

Global T, Strategy L, Strat L, Strat L. Weekly epidemiological record Relevé épidémiologique hebdomadaire. WHO. 2018;(35):445–56.

Pranata M, Nugrahaini ARDN, Fajariah N. Characteristics and Therapy in Leprosy Patients at The Semarang City of Tugurejo Hospital. Med Sains. 2022;7(4):943–50.

Osadolor HB, Okosun R. Non-enzymatic antioxidants status of leprosy patients in a leprosarium settlement in Nigeria. Biokemistri. 2014;26(June):50–4.

Garg V, Garg RK, Rizvi I, Suvirya S, Malhotra HS, Jain A, et al. Vitamin a, c, d, e and b12 levels in leprosy: A case-control study. Indian J Lepr. 2020;92(2):81–8.

Vijayaraghavan R, Suribabu CS, Sekar B, Oommen PK, Kavithalakshmi SN, Madhusudhanan N, et al. Protective role of vitamin E on the oxidative stress in Hansen’s disease (Leprosy) patients. Eur J Clin Nutr. 2005;59(10):1121–8.

Schalcher TR, Borges RS, Coleman MD, Júnior JB, Salgado CG, Vieira JLF, et al. Clinical oxidative stress during leprosy multidrug therapy: Impact of dapsone oxidation. PLoS One. 2014;9(1).

Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of Vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85–94.

Downloads

Published

2023-10-12

How to Cite

1.
Hazlianda CP, Dalimunthe DA, Partogi D. Analysis of vitamin E in leprosy patients . J Pak Assoc Dermatol [Internet]. 2023Oct.12 [cited 2024Nov.11];33(4):1238-41. Available from: https://jpad.com.pk/index.php/jpad/article/view/2334

Issue

Section

Original Articles

Most read articles by the same author(s)