The impact of COVID-19 infection on botulinum toxin hypersensitivity: Case report and literature review

Authors

  • Thamir Kubaisi University of Anbar
  • Khalifa Sharquie Department of Dermatology, College of Medicine, University of Baghdad, Center of Dermatology, Medical City Teaching Hospital, Baghdad, Iraq.

Keywords:

COVID-19, Botulinum toxin hypersensitivity, Periorbital swelling, Face wrinkles

Abstract

COVID-19 infection showed specific and nonspecific triggering of the immune system with different skin manifestations. Botulinum neurotoxin type A is the most commonly used injectable drug in a cosmetic procedure, and there are few reports regarding the interaction with COVID-19. Herein, an adult woman underwent a local cosmetic botulinum neurotoxin type A injection and unfortunately, at the same time, she was diagnosed with COVID-19 infection. After 4 hours following injection, the patient developed local pain and pruritus with periorbital swelling and red plaques involving the medial canthus and lower eyelids, with erythema that spread to both cheeks. Previously, she had a history of uncomplicated twice cosmetic botulinum neurotoxin type A procedures for face wrinkles. An outpouring of several cases of hyper-reactivity to cosmetic botulinum neurotoxin type A might happened during COVID-19 pandemic. During cosmetic procedures, dermatologists and plastic surgeons should be aware of the possibility of life-threatening anaphylaxis that might happen during COVID-19 infection or its vaccination.

References

Arora G, Arora S, Talathi A, Kandhari R, Joshi V, Langar S, et al. Safer practice of aesthetic dermatology during the COVID-19 pandemic: Recommendations by SIG aesthetics (IADVL Academy). Indian Dermatol Online J. 2020;11(4):534.

Alhujayri AK, Alyousef LA, Alharthi SA, Aldekhayel S. Perception of Cosmetic Procedures among Saudis during COVID-19 Pandemic. Plast Reconstr Surg Glob Open. 2021;9(6):3710.

Witmanowski H, Błochowiak K. The whole truth about botulinum toxin – A review. Postepy Dermatol Alergol. 2020;37(6):853-861.

Rosenfield LK, Kardassakis DG, Tsia KA, Stayner G. The first case report of a systemic allergy to onabotulinumtoxinA (Botox) in a healthy patient. Aesthet Surg J. 2014;34(5):766–8.

Pickett A. Can botulinum toxin cause anaphylaxis after an aesthetic treatment? Clinical and Experimental Dermatology. 2018;43:599–600.

Farhood, I. G., AbdulHasan, A. T., Lafta, S. F., Mamoori, A., & Al-Hasani, F. Dermatological Manifestations of Patients with COVID 19: A Cross-sectional study. Al-Anbar Medical Journal. 2022;18(1):43-47.‏

Careta MF, Delgado L, Patriota R. Report of allergic reaction after application of botulinum toxin. Aesthet Surg J. 2015;35(5):102–5.

Moon IJ, Chang SE, Kim SD. First case of anaphylaxis after botulinum toxin type A injection. Clin Exp Dermatol. 2017;42(7):760–2.

Akdogan N. Severe hyperalgesia and pain during botulinum toxin injection avoiding application in a patient 1 week after COVID-19 infection. Journal of Cosmetic Dermatology. 2021;20:755–6.

Guo X, Li T, Wang Y, Jin X. Sub-acute hypersensitive reaction to botulinum toxin type A following Covid-19 vaccination: Case report and literature review. Medicine (United States). 2021;100(49).

Marzano A v., Cassano N, Genovese G, Moltrasio C, Vena GA. Cutaneous manifestations in patients with COVID-19: a preliminary review of an emerging issue. British Journal of Dermatology. 2020;183:431–42.

Kubaisi TA. A neglected pyoderma gangrenosum following COVID-19: A case report. Journal of Pakistan Association of Dermatologists. 2023;33(1):345-349.

Akdogan N. Severe hyperalgesia and pain during botulinum toxin injection avoiding application in a patient 1 week after COVID-19 infection. Journal of Cosmetic Dermatology. 2021;20:755–6.

Ahbib S, Lachapelle JM, Marot L. Granulomes sarcoïdosiques après injections de toxine botulique A (Botox®) pour correction de rides. Ann Dermatol Venereol. 2006;133(1):43–5.

Wang C, Sun T, Li H, Li Z, Wang X. Hypersensitivity Caused by Cosmetic Injection: Systematic Review and Case Report. Aesthetic Plastic Surgery. 2021;45:263–72.

Rutkowski K, Dua S, Nasser S. Anaphylaxis: Current state of knowledge for the modern physician. Postgraduate Medical Journal. 2012; 88: 458–64.

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Published

2023-10-12

How to Cite

1.
Kubaisi T, Sharquie K. The impact of COVID-19 infection on botulinum toxin hypersensitivity: Case report and literature review. J Pak Assoc Dermatol [Internet]. 2023Oct.12 [cited 2024May22];33(4):1762-6. Available from: https://jpad.com.pk/index.php/jpad/article/view/2313

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Section

Case Reports