New Onset Bullous Pemphigoid After COVID-19 Inactivated Virus Vaccination: A Case Report
Keywords:bullous pemphigoid, covid-19 vaccination, inactivated virus, SARS-COV-2
AbstractBullous pemphigoid (BP) is an autoimmune bullous disease caused by circulating immunoglobulins G (IgG) against hemidesmosome antigens commonly found in elderly patients. Pemphigoid cases have been reported in association with vaccination. Cases of subepidermal blistering eruptions including BP had also been reported after COVID-19 vaccination. Here we report a case of an elderly woman who developed BP after receiving SARS-CoV-2 inactivated virus vaccine. She was presented to our hospital with a pruritic blistering eruption which started 10 days after her second dose of SARS-CoV-2 inactivated virus vaccine. She had a history of pruritic redness skin lesions on her arms and legs that appeared seven days after her first dose of vaccine. Histopathology and direct immunofluorescence examination were suggesting BP. Symptoms were improved after oral and topical corticosteroid treatment. The timeline of vaccination and appearance of blistering skin lesions suggesting possible association between BP and COVID-19 vaccination. We should be aware that the onset or flare-up of BP can occur after vaccination in the elderly.
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