Plateletcrit levels in patients with psoriasis and its relationship with psoriasis disease severity
Plateletcrit levels in patients with psoriasis and disease severity
Keywords:Plateletcrit levels, Pustular psoriasis., Psoriasis disease severity, Psoriasis area and severity index
AbstractObjective The main aim of study was to determine mean plateletcrit level in patients of psoriasis and to compare mean platelecrit level in patients of psoriasis with psoriasis area and severity index < 10 and ≥10. Methods It was a single-center, cross-sectional study carried out at the Department of Dermatology, Pakistan Airforce Hospital, Fazaia Medical College, Islamabad. The study was conducted from 12 October 2020 to 11 April 2021 over a six-month period. Following informed consent, 100 known psoriasis patients were recruited to the study. Proper history was taken, and examination was done to determine disease severity. By computing the Psoriasis Area and Severity Index (PASI), the severity of the disease was evaluated. Plateletcrit level was also determined and was correlated with Psoriasis area and severity index to see if plateletcrit level is increased with score which shows the severity of the disease. Results Mean age of the patients was 44 years. Majority of the patients were males. Mean BMI was 24.7 (kg/m2). Out of 100 patients, 77 (77%) were having psoriasis area and severity index score < 10 while 23 (23%) were having PASI score ≥ 10. Mean value of plateletcrit in patients of psoriasis was 0.284. Mean plateletcrit, in with PASI <10 and PASI ≥10 was 0.261and 0.360 subsequently. Statistics showed that there was a significant difference between the two groups (p˂0.001). Conclusion In conclusion, patients with PASI ≥10, who have psoriasis had higher mean plateletcrit values. In this study, a connection between platetcrit and the severity of psoriasis is established. Given that this is a straightforward test that is part of a full blood analysis. However, thorough interventional trials and translational research are required to better examine the precise clinical significance of plateletcrit in psoriasis.
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