Regular sports exercises as a supportive therapeutic choice in cholinergic urticaria


  • Thamir Kubaisi Department of Dermatology, College of Medicine, University of Anbar; Ramadi, Anbar, Iraq.


Sports exercises, Cholinergic urticarial, Quality of life, Oral antihistamine, Acquired hypohidrosis


Background Cholinergic urticaria characterizes by stinging pain and/or itching usually occurring after sweating, and frequently associated with disturbance in the quality of life. Many patients resist conventional treatment and have sweat hypersensitivity. Objective To emphasize the role of regular daily exercise as a possible supportive treatment for cholinergic urticaria, in addition to an oral antihistamine. Method Randomized cross-section comparative therapeutic study for 240 patients with cholinergic urticaria, screened from January 2021 to December 2022 at Dermatology and Venereology Private Clinic, Anbar, Iraq. A history was taken regarding the age, sex, onset and duration of illness, seasonal variation, presenting symptoms and signs, and time of the attack. Participants were randomly divided into 3 groups of 80 cases each. They were asked to complete a questionnaire of the urticaria activity score over 7 days- twice daily version. Only moderate to severe cholinergic urticaria were enrolled in this study.  Results The mean (range) age was 25.5 (18-45) years, 153 (63.8%) males and 87(36.2%) females. While 153 (63.8%) of patients presented in winter months. Generalized discomfort, acquired hypohidrosis, itching, and tingling were present in 234 (97.5%), 192 (80%), 177 (73.8%), and 63 (26.2%) individuals respectively. In comparison to each therapy alone, patients who used both oral levocetirizine 5mg/ day plus daily physical exercise for 30 minutes showed significantly marked improvement in 53(66.3%) of cases within 1st week, and 63(78.8%) of subjects at end of 2 weeks of therapy.   Conclusion Regular daily exercises plus H1 antagonists are beneficial for full recovery in the life quality for the majority of patients complaining of severe cholinergic urticaria. Generalized discomfort and acquired hypohidrosis are significantly correlating with disease existence.    Keywords Sports exercises, Cholinergic urticaria, Quality of life, Oral antihistamine, Acquired hypohidrosis


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How to Cite

Kubaisi T. Regular sports exercises as a supportive therapeutic choice in cholinergic urticaria. J Pak Assoc Dermatol [Internet]. 2023Oct.12 [cited 2023Nov.28];33(4):1298-305. Available from:



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