A clinico-pathological study of cutaneous tumors in a tertiary care centre of Eastern India

Authors

  • Prodip Sarkar MEDICAL COLLEGE KOLKATA
  • Karunamoy Chakrabarty
  • Supratim Karmakar
  • Partha Sarathi Nayak Medical College Kolkata
  • RAMESH GHARAMI
  • Sukumar Jana

Keywords:

Cutaneous tumors, Histopathology, Seborrheic keratosis, Squamous cell carcinoma, Basal cell

Abstract

Introduction: There is a huge spectrum of cutaneous tumors ranging from small papules to large fungating masses. Due to diversity of these tumors, there can be confusion regarding nomenclature of these tumors. Skin tumors can be confused clinically with malignancies, particularly when they are pigmented or inflamed. Hence, histopathological examination of a biopsy specimen is required to establish a definitive diagnosis and to facilitate appropriate intervention and follow up.  As a result, the study of skin tumor is perhaps more interesting and challenging than any other tumors. The present study aimed at studying the clinical profile of various benign and malignant cutaneous tumors and establishing their clinico-pathological correlation. Materials & Methods: A total of 102 consecutive patients of cutaneous tumors fulfilling the eligibility criteria were included in the study. After taking informed consent, detailed history, clinical examination and routine laboratory investigations were carried out on requirement basis. Skin biopsy was taken from representative areas and submitted for routine processing. Correlation of clinical findings with histopathological results was done to establish a final diagnosis. Results: Out of total 102 patients, 80.4% were presented with benign conditions while 19.6% were presented with malignant conditions. Most common type of tumor observed in present study was Keratinocytic (42.2%) followed by Melanocytic (18.6%). Most common individual tumor observed was Seborrheic Keratosis (27.5%), followed by Melanocytic Nevus (14.7%) and Syringoma (11.7%), while (8.8%) and (5.9%) cases of SCC and BCC were observed. Most of the pathologies were presented as either papule (55.9%) or plaque (21.6%). Growth was observed in 6 cases of SCC and two cases of melanoma. Conclusion: Seborrheic keratosis is the most common benign tumor while SCC and BCC were the most common malignant skin tumors in the study. Histopathological study is a very important step in the diagnosis of skin tumors. Key words: Cutaneous tumors, Histopathology, Seborrheic keratosis, Squamous cell carcinoma, Basal cell carcinoma.  

References

References

Fletcher, Christopher DM, K. Krishnan Unni, and Fredrik Mertens, eds.Pathology and genetics of tumours of soft tissue and bone. Vol. 4. Iarc, 2002.

Pinkus Hermann, Mehregan A.H. — Normal structure of skin. In: Pinkus Hermann. AGuide to dermatohistopathology. 3rd ed. Appleton- Century – Crofts/ NewYork, 1981; 5-38.

Luba M., Bangs S., Mohler A., Stulberg D.L. — Common benign skin tumours. Am Fam Physician. 67(4):729-738, 2003.

Deo S.V., Hazarika S., Shukla N., Kumar S., Kar M., Somaiya A. — Surgical management of skin cancers: Experience from a regional cancer centre in North India. Ind J Cancer. 42:145-150, 2005.

Bari, Vaibhav, et al. "Skin Tumours–Histopathological Review of 125 Cases."Indian Medical Gazette (2014): 419.

Reddy D.J., Rao K.V. — Malignant neoplasms of the skin. Ind J Dermatol Venerol. 30:43-54, 1964.

Khalid M., Khalid A., Bhat M., Ramesh V., Syed M. — Skin tumours in western Saudi Arabia. Saudi Med J. 24(12):1381-1387, 2003.

Ochicha O., Edino S.T., Mohammed A.Z., Umar A.B. — Dermatological malignancies in Kano, Northern Nigeria: a histopathological review. Ann Afrc Med. 3(4):188-191, 2004.

Chakravarthy R.C., Choudhari. Malignant neoplasms of skin in Eastern India. Ind J Cancer. 5(1):133-144, 1968.

Har-Shai Y., Hai N., Taran A., Mayblum S., Barak A., Tzur E. et al. — Sensitivity and positive predictive values of presurgical clinical diagnosis of excised benign and malignant skin tumours: a prospective study of 835 lesions in 778 patients. Plast Reconstr Surg. 108(7):1982- 1989, 2001

Budhraja S.N., Pillai V.C.V., Perianayagam W., Kaushik S., Bedi B. — Malignant neoplasms of the skin in Pondicherry (a study of 102 cases). Ind J Cancer. 284- 295, 1972.

Deo S.V., Hazarika S., Shukla N., Kumar S., Kar M., Somaiya A. — Surgical management of skin cancers: Experience from a regional cancer centre in North India. Ind J Cancer. 42:145-150, 2005.

Kapoor R., Goswami K.C. — Pattern of cancer in Jammu region (Hospital based study 1978-89). Ind J Cancer. 30:67-71, 1993.

Kulkarni P.V., Jaiswal S.S. — Profile of malignancies at medical college. Ambajogai (15 years retrospective study). Ind J Cancer. 33:31-36, 1996.

Kirkham N. — Tumours and cysts of the epidermis. In: Elder DE, eds. Lever s Histopathology of skin, 9th ed. Lippincott Williams & Wilkins, 2005; 805-866.

Soomero F.R., Bajaj D.R., Pathan G.M., Abbasi P., Hussain J., Abbasi S.A. — Cutanous malignant tumours: a profile of ten years in LINAR, Larkana_Pakistan. J Pak Asso Dermatologists. 20:133-136, 2010.

Zohreh H., Golpour M., Ghasemi M. — Aclinicopathologic review of skin cancers in Sari in north-east of Iran (1996- 2006). The Internet Journal of Epidemiology. 5(1), 2007

Solanki R.L., Arora H.L., Anand V.K., Gaur S.K., Gupta R. — Basal cell epithelioma. Indian J Dermatol Venerol Leprol. 55: 33-37, 1989.

David W. — Tumors of the epidermis. In: Weedon D. Skin Pathology. 2 nd ed. Churchill Livingstone, 754-782, 2002.

Downloads

Published

2023-10-12

How to Cite

1.
Sarkar P, Chakrabarty K, Karmakar S, Nayak PS, GHARAMI R, Jana S. A clinico-pathological study of cutaneous tumors in a tertiary care centre of Eastern India. J Pak Assoc Dermatol [Internet]. 2023Oct.12 [cited 2024Oct.5];33(4):1454-60. Available from: https://jpad.com.pk/index.php/jpad/article/view/2283

Issue

Section

Original Articles

Most read articles by the same author(s)