Positivity Rate of Autologous Plasma Skin Test and Autologous Serum Skin Test in Chronic Spontaneous Urticaria
Keywords:chronic spontaneous urticaria, screening test, autologous plasma skin test, autologous serum skin test, urticaria activity score
AbstractBackground: Autologous plasma skin test (APST) and autologous serum skin test (ASST) are simple, semi-invasive, inexpensive, and easy to perform diagnostic test for chronic spontaneous urticaria (CSU). However, the positivity rate of both tests was varied. The study aims to compare the positivity rate of APST and ASST in patients with CSU, and correlate with urticaria activity. Method: This study included 36 CSU patients underwent testing with APST and ASST. Urticaria activity was assessed by urticaria activity score over 7 days (UAS7). We observed positivity APST and ASST among moderate-severe and mild urticaria activity Result: Twenty-two of 36 CSU patients was female, with mean age was 28± 9.969 years old. The positivity rate of APST was higher than ASST (83.33% vs 66.67%). Positive APST with negative ASST were 25%, meanwhile negative APST with positive ASST were 8.33%. Not only were no statistically significant differences in APST and ASST, but also age, sex, and ASST diameter with urticaria activity (p = 0,378, p = 0.968, p = 1.000, p = 0.826, respectively). The positiveness rates of APST were significantly higher in the patient with moderate-severe activity than mild activity (p = 0.008). Conclusion: In conclusion, positivity rate of APST was higher than ASST among patients with CSU. Furthermore, positivity APST was associated with moderate-severe urticaria activity, and may considered as a screening test to predict urticaria activity in CSU patients.
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