Triple therapy of Kaposi’s sarcoma using oral propranolol,oral zinc sulfate and oral acyclovir as new initiative study

Authors

  • Khalifa E. Sharquie Department of Dermatology, College of Medicine, University of Baghdad. Medical City Teaching Hospital,Baghdad ,Iraq
  • Raed I. Jabbar Department of Dermatology ,Fallujah Teaching Hospital ,Al-Anbar Health Directorate , Anbar , Iraq.

Keywords:

Kaposi’s Sarcoma, triple therapy, zinc sulfate, acyclovir

Abstract

Background  Kaposi’s sarcoma (KS) in Iraq had been reported as sporadic cases in elderly of Iraqi population but after the Gulf War 1991, there was marked increase in cases of classic KS among Iraqi people, in concordance with the rise of incidence of other hematological and skin malignancies.   Objective To introduce triple therapy for Kaposi’s sarcoma using oral propranolol, oral zinc sulfate and oral acyclovir as new innovative therapy.   Methods This is case series and therapeutic trial in which seven cases with histopathological proved Kaposi’s sarcoma were included over a twelve months period from 2021 to 2022. All patients were treated by oral propranolol tablet 20mg three times a day, with oral zinc sulfate 100 mg three times a day and acyclovir tablet 800mg three times a day. The duration of therapy continued for three months apart from one case in which the treatment continued for one year. Patients were watched carefully for response to therapy and any adverse reactions were recorded.   Results A total of 7 cases of Kaposi’s sarcoma enrolled in this study during one-year period (2020-2021). The age of the patients ranged from 50-60 years with 6 (85.71%) males and one (14.28%) female. The duration of the skin lesions ranged from 2 to 13 months with a mean±SD of 7.85±3.97 months. The lower limbs were the most commonly involved site in 4 (57.14%) cases. In all patients the improvement to therapy was started two weeks after starting the treatment. After 3 weeks, all patients showed obvious decrease in the size of the skin lesions with marked reduction in the size of the lesions achieved after 1.5 months. Ultimately, the lesions and associated signs and symptoms were completely vanished after three months leaving only hyperpigmented macules or patches.   Conclusion This is new effective innovative triple therapy for Kaposi sarcoma using oral propranolol, oral zinc sulfate and oral acyclovir. This new regimen of treatment has both therapeutic and prophylactic effects. Further studies are highly recommended using large series of patients and longer duration of therapy to have more confirmed therapeutic response.  

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Published

2023-03-05

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1.
Sharquie KE, Jabbar RI. Triple therapy of Kaposi’s sarcoma using oral propranolol,oral zinc sulfate and oral acyclovir as new initiative study . J Pak Assoc Dermatol [Internet]. 2023Mar.5 [cited 2024May22];33(1):72-7. Available from: https://jpad.com.pk/index.php/jpad/article/view/2060

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