Prevalence of elevated testosterone levels among female patients of acne vulgaris

Authors

  • Naila Tabassum Department of Dermatology, Services Hospital/ Services Institute of Medical Sciences, Lahore
  • Hira Tariq Department of Dermatology, Services Hospital/ Services Institute of Medical Sciences, Lahore
  • Saelah Batool Department of Dermatology, Services Hospital/ Services Institute of Medical Sciences, Lahore
  • Zahra Arooba Department of Dermatology, Services Hospital/ Services Institute of Medical Sciences, Lahore
  • Azam Bukhari
  • Shahbaz Aman Department of Dermatology, Services Hospital/ Services Institute of Medical Sciences, Lahore

Keywords:

Serum testosterone, acne, chemiluminescence technology

Abstract

Background  Acne vulgaris is a frequently encountered skin disorder among patients of all ages. It is a source of significant psychosocial trauma and reduced self-esteem especially among females. Androgens, mainly testosterone, have a significant role in its pathogenesis. They mainly increase the sebum production that plays an important role in the formation of typical lesions of acne.   Objective To assess the frequency of increased levels of testosterone among female patients of acne.   Methods This cross-sectional survey was carried out at Department of Dermatology Services Hospital/ Services Institute of Medical Sciences, Lahore from 1st June, 2018 till 30th November, 2018. 3 ml of blood sample was drawn from each patient on 2nd day of menstrual cycle. Serum testosterone analysis was done using chemiluminescence technology. The level of serum testosterone >120 ng/dl was taken as high.   Results A total of 220 female patients of acne were enrolled. Mean age of the patients was 22.7±5.4 years. Mean duration of disease was 11.8±8.7 months, while mean BMI was 24.38±3.80 kg/m2. High serum testosterone level was observed in 22 patients (10%). Statistically significant effect of age, BMI, marital status and severity of acne was noted on elevated testosterone levels.   Conclusion It was observed that high serum testosterone was significantly associated with acne. Therefore, assessment of testosterone levels and androgen based treatments may help in better management of women presenting with acne.  

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Published

2023-03-05

How to Cite

1.
Naila Tabassum, Hira Tariq, Saelah Batool, Zahra Arooba, Azam Bukhari, Shahbaz Aman. Prevalence of elevated testosterone levels among female patients of acne vulgaris. J Pak Assoc Dermatol [Internet]. 2023Mar.5 [cited 2024May19];33(1):91-5. Available from: https://jpad.com.pk/index.php/jpad/article/view/2039

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