Successful treatment of Epidermolysis Bullosa Pruriginosa with Cyclosporine

Abstract

Abstract Epidermolysis  bullosa  (EB)  pruriginosa  is  a  rare  clinical  subtype  of  dystrophic  epidermolysis  bullosa  (DEB)  that  is  characterized  by  intense  pruritus  resulting  in  hypertrophic,  lichenified,  prurigo-like  plaques  and  nodules  secondary  to  scratching. The variability in the age of onset, rarity of intact bullae, histologic ambiguities and close resemblance to other conditions such as acquired inflammatory dermatoses may make diagnosis difficult for this unusual condition. In this report, we describe a case of 23 years old male who presented with blistering and pruritus with no family history of the disease. He had taken multiple medications without much relief so we gave him Cyclosporine which proved to be effective in relieving his symptoms and blistering.