Cutaneous manifestations in obesity
Keywords:
Cutaneous manifestation, obesity, acanthosis nigricansAbstract
Objective To study the frequency of various dermatoses in obese patients and their comparison with the control group of normal weight individuals. Methods The duration of study was one year starting from March 2011 to March 2012. A total of 93 obese (BMI >30kg/m2) and 93 normal weight (BMI 18.5-24.9 kg/m2) individuals were included in the study. All the individuals underwent a complete medical and dermatological evaluation. All of them were evaluated for the presence of metabolic syndrome, as well. Results Common dermatoses seen in obese patients were acanthosis nigricans, striae, acrochordons, and various infections. Out of these acanthosis nigricans, acrochordons and striae had statistically significant relationship with obesity as compared to control group (p<0.05). All the manifestations were also compared for diabetes, dyslipidemia and metabolic syndrome. Conclusion Obesity is associated significantly with certain dermatoses. Understanding and thorough knowledge of these disorders is necessary both for the physicians as well as for a dermatologist, as many of these conditions are treatable, leading to an improved life quality. Early recognition of these lesions may also warn the patients for a need of weight reduction.References
Baskin ML, Ard J, Frauklin F, Allison DB. Prevalence of obesity in the United States. Obes Rev. 2005;6:5-7.
Wolf AM, Colditz GA. Current estimates of the economic cost of obesity in the United States. Obes Res. 1998;6:97-106.
Lenz M, Richter L, Muhlhauser I. The morbidity and mortality associated with overweight and obesity in adulthood: a systematic review. Dtsch Arztebl Int. 2009;106:641-8.
Pender JR, Pories WJ. Epidemiology of obesity in the United States. Gastroenterol Clin North Am. 2005;34:1-7.
Garcia-Hidalgo L. Dermatological complications of obesity. Am J Clin Dermatol. 2002;3:497-506.
Boza JC, Trindade EN, Peruzzo J et al. Skin manifestations of obesity: a comparative study. J Eur Acad Dermatol Venereol. 2012;26:1220-3.
Garcia-Hidalgo L, Orozco-Topete R, Gonzalez-Barranco J et al. Dermatoses in 156 obese adults. Obes Res. 1999;7:299-302.
Al-Mutairi N. Associated cutaneous diseases in obese adult patients: a prospective study from a skin referral care centre. Med Princ Pract. 2011;20:248-52.
Hermanns-Le T, Scheen A, Pierard GE. Acanthosis nigricans associated with insulin resistance: pathophysiology and management. Am J Clin Dermatol. 2004;5:199-203.
Hud JA Jr, Cohen JB, Wagner JM, Cruz PD Jr. Prevalence and significance of acanthosis nigricans in adult obese population. Arch Dermatol. 1992;12:941-4.
Araujo L, Viveros A, Lopes R, Viana A et al. Acanthosis nigricans em mulheres obesas de uma populacao miscigenada: um marcador de di strubios metabolicos. An Bras Dermatol. 2002;77:537-43.
Tamega Ade A, Aranha AM, Guiotoka MM et al. Association between skin tags and insulin resistance. An Bras Dermatol. 2010;85:25-31.
Jowkar F, Fallahi A, Namazi MR. Is there any relation between serum insulin and insulin like growth factor-1 in non-diabetic patients with skin tag? J Eur Acad Dermatol Venereol. 2010;24:73-4.
Hus HS, Chen W, Chen SC, Ko FD. Colored striae in obese children and adolescents. Zhonghua Min Guo. Xia Er Ke Yi Xue Hui Za Zhi. 1996;37:349-52.
Cho S, Park ES, Lee DH et al. Clinical features and risk factors for striae distensae in Korean adolescents. J Eur Acad Dermatol Venereol. 2006;20:1108-113.
Aoyama T, Francke U, Gasner C, Furthmayr H. Fibrillin abnormalities and prognosis in Marfan syndrome and related disorders. Am J Med Genet. 1995;58: 169-176.
McKusick VA. Transverse striae distensae in the lumbar area in father and two sons. Birth Defects. 1971;58:169-76.
Janniger CK, Schwartz RA, Szepietowski JC, Reich A. Intertrigo and common secondary skin infections. Am Fam Physician. 2005;72:833-8.
Hercogova J, Ricceri F, Tripo L et al. Psoriasis and body mass index. Dermatol Ther. 2010;23:152-4.
Armstrong AW, Harskamp CT, Armstrong EJ. The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies. Nutr Diabetes. 2012;26:1-6.