Acanthosis nigricans: An extensive review


  • Sajad Ahmad Salati Unaizah College of Medicine , Qassim University , Saudi Arabia
  • Leenah Abdullah Alqarawi Unaizah College of Medicine , Qassim University , KSA
  • Yomna Fozan Alquraishi Unaizah College of Medicine , Qassim University , KSA


acanthosis nigricans (AN), insulin resistance, endocrine disorders, obesity, paraneoplastic syndrome, growth factors, hyperpigmentation, differential diagnosis.


Acanthosis nigricans (AN) is a velvety, hyperpigmentation of the skin that usually occurs in intertriginous areas. AN is most commonly associated with benign disorders like diabetes, insulin resistance, endocrinopathies and exogenous medications, but can be a valid cutaneous marker of a wide range of internal malignancies, which makes it important for the physicians across specialties to have awareness about it. With an increase in the prevalence of obesity and diabetes in recent decades, the prevalence of AN has also shown a significant increase. This article will review in detail the epidemiology, pathophysiology, clinical features and treatment of acanthosis nigricans in the light of the literature

Author Biographies

Sajad Ahmad Salati, Unaizah College of Medicine , Qassim University , Saudi Arabia

Associate Professor , Department of SurgeryUnaizah College of Medicine , Qassim University , Saudi Arabia

Leenah Abdullah Alqarawi, Unaizah College of Medicine , Qassim University , KSA

Department of Surgery

Yomna Fozan Alquraishi, Unaizah College of Medicine , Qassim University , KSA

Department of Surgery


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