A clinico-pathological study of cutaneous vasculitis in a tertiary hospital of North India

Authors

  • Jaspriya Sandhu Dayanand Medical College& hospital Ludhiana, Punjab India 141001
  • Sunil Kumar Gupta
  • Bhavna Garg
  • Neena Sood

Keywords:

cutaneous vasculitis, clinico-pathological features of vasculitis

Abstract

Objective Cutaneous vasculitis is often seen in dermatological practice. The etiology maybe infections, drugs, connective tissue disease among others. The objective of this study was to study the clinico-pathological features in patients of cutaneous vasculitis who underwent biopsy. Methods In this retrospective study, data of patients diagnosed with Cutaneous Vasculitis who underwent biopsy over a 3-year-period, between January 2016 and December 2018 was taken. Results There were 53 patients, with slight female preponderance [(F=27 (50.9%), M=26 (49.1%). Mean age= 32.15 years]. The most common cutaneous presentation was palpable purpura seen in 36 patients (67.8%).The most common form was Cutaneous small vessel vasculitis (CSVV) seen in 29 patients (54.7%), followed by Urticarial vasculitis (UV) in 13.2%. Prior drug intake (9.4%) appeared to be the most common eliciting factor. Direct immunofluorescence was done in 10 patients, where it was found to be negative.. Conclusion The most commonly seen vasculitis were CSVV and UV. An eliciting factor was found in 22.6% of our patients. Among the histopathological features, there was a statistically significant correlation between the presence of endothelial swelling and HSP, and urticarial infiltrate with UV. No association of drug history with tissue eosinophilia was found. DIF was negative in all 10 patients. 

References

Arora A, Wetter DA, Gonzalez-Santiago TM, Davis MD, Lohse CM. Incidence of leukocytoclastic vasculitis, 1996 to 2010: a population-based study in Olmsted County, Minnesota. Mayo Clinic proceedings. 2014;89(11):1515-24.

Hunder GG, Arend WP, Bloch DA, Calabrese LH, Fauci AS, Fries JF, et al. The American College of Rheumatology 1990 criteria for the classification of vasculitis. Introduction. Arthritis and rheumatism. 1990;33(8):1065-7.

Jennette JC. Overview of the 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Clinical and experimental nephrology. 2013;17(5):603-6.

Khetan P, Sethuraman G, Khaitan B, Sharma V, Gupta R, Dinda A, et al. An aetiological & clinicopathological study on cutaneous vasculitis. Indian Journal of Medical Research. 2012;135(1):107-13.

Poornimambaa M, Asokan N, Augustine J. Utility of direct immunofluorescence in the diagnosis of small vessel vasculitis of the skin: A cross-sectional study. Indian Dermatology Online Journal. 2017;8(6):515-7.

Nandeesh B, Tirumalae R. Direct immunofluorescence in cutaneous vasculitis: Experience from a referral hospital in India. Indian Journal of Dermatology. 2013;58(1):22-5.

Latha S, Choon SE, Tey KE, Chee YN. Clinical features and prognostic factors of cutaneous vasculitis among dermatology patients in Johor Bahru, Malaysia. The Medical journal of Malaysia. 2017;72(6):345-9.

Blanco R, Martinez-Taboada VM, Rodriguez-Valverde V, Garcia-Fuentes M. Cutaneous vasculitis in children and adults. Associated diseases and etiologic factors in 303 patients. Medicine. 1998;77(6):403-18.

Tai YJ, Chong AH, Williams RA, Cumming S, Kelly RI. Retrospective analysis of adult patients with cutaneous leukocytoclastic vasculitis. The Australasian journal of dermatology. 2006;47(2):92-6.

Boom BW, Mommaas M, Daha MR, Vermeer BJ. Complement-mediated endothelial cell damage in immune complex vasculitis of the skin: ultrastructural localization of the membrane attack complex. The Journal of investigative dermatology. 1989;93(2 Suppl):68s-72s.

Bahrami S, Malone JC, Webb KG, Callen JP. Tissue Eosinophilia as an Indicator of Drug-Induced Cutaneous Small-Vessel Vasculitis. JAMA Dermatology. 2006;142(2):155-61.

Davis MD, Brewer JD. Urticarial vasculitis and hypocomplementemic urticarial vasculitis syndrome. Immunology and allergy clinics of North America. 2004;24(2):183-213, vi.

Johnson EF, Wetter DA, Lehman JS, Hand JL, Davis DM, Tollefson MM. Leukocytoclastic vasculitis in children: clinical characteristics, subtypes, causes and direct immunofluorescence findings of 56 biopsy-confirmed cases. Journal of the European Academy of Dermatology and Venereology : JEADV. 2017;31(3):544-9.

Gupta S, Handa S, Kanwar AJ, Radotra BD, Minz RW. Cutaneous vasculitides: clinico-pathological correlation. Indian journal of dermatology, venereology and leprology. 2009;75(4):356-62.

Al-Mutairi N. Spectrum of cutaneous vasculitis in adult patients from the Farwaniya region of Kuwait. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2008;17(1):43-8.

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Published

2020-10-01

How to Cite

1.
Sandhu J, Gupta SK, Garg B, Sood N. A clinico-pathological study of cutaneous vasculitis in a tertiary hospital of North India. J Pak Assoc Dermatol [Internet]. 2020Oct.1 [cited 2025Jan.20];30(3):441-8. Available from: https://jpad.com.pk/index.php/jpad/article/view/1466

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