Evaluation of serum 25 hydroxy vitamin D levels in patients with chronic spontaneous urticaria: a hospital based cross sectional study in a tertiary care centre
Keywords:
Chronic spontaneous urticaria, 25 hydroxy vitamin D, UAAbstract
Background Chronic spontaneous urticaria (CSU) is considered as one of the most difficult to treat condition in dermatology. Several studies showed low levels of vitamin D in these patients and believed to have role in pathogenesis of CSU. Aim To evaluate serum 25 hydroxy vitamin D levels (25-(OH) D) in patients with chronic spontaneous urticarial (CSU) and to know its association with the disease activity. Material and Method This was a hospital based cross sectional study conducted over 18 months which included 50 cases of CSU and 50 age and sex matched controls. In each case, detailed history and physical examinations were carried out and urticaria activity score [UAS] was calculated. 25-(OH)D level was measured both in cases and controls using enzyme immunoassay method [EIA]. Those with 25-(OH) D levels < 20 ng/mL were labelled as deficient, between 20 and 30 labelled as insufficient and any value > 30 ng/mL were labelled normal. Appropriate statistical tests were done to analyse the data. Results The mean 25-(OH) D levels among the cases was 34.02 and among the controls it was 48.9, the difference was statistically significant (p value = 0.000771). No significant correlation was observed between 25-(OH) D levels and UAS. Conclusion  Patients with CSU had low serum 25-(OH) D when compared to healthy controls and no correlation was observed between 25-(OH)D and disease activity (assessed based on UAS).ÂReferences
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