Autoimmune progesterone dermatitis presented as acute generalized exanthematous pustulosis

Suchibrata Das, Sangita Patra, Saikat Banerjee, Saswati Das


Autoimmune progesterone dermatitis (AIPD) is a rare autoimmune response to endogenous progesterone, characterized by cyclic cutaneous and mucosal lesions at the end of the luteal phase with varied type of skin lesions include urticaria, angioedema, erythema multiforme, eczema, folliculitis, papulovesicular eruptions, fixed drug eruption, purpura, or vulvovaginal pruritus and anaphylaxis. We report a case of AIPD presenting as acute generalized exanthematous pustulosis (AGEP). She had papulovesicular lesions with sheet of pustules that appeared in relation with menstrual cycle. Progesterone intradermal test was positive. She was treated successfully with combination oral pills.



Autoimmune progesterone dermatitis, cyclical, acute generalized exanthematous pustulosis

Full Text:



Millington GWM, Graham-Brown RAC. Skin and skin disease throughout life. In: DA Burns, SM Breathnach, NH Cox, CEM Griffins, editors. : Rooks”s Textbook of dermatology, 8th edition. Blackwell Publishing Ltd. New York, 2010; p 8.8

M.K. Lee, W.Y. Lee, S.J. Yong, K.C. Shin, S.N. Lee, S.J. Lee, et al. A case of autoimmune progesterone dermatitis misdiagnosed as allergic contact dermatitis. Allergy Asthma Immunol Res, Volume 3, 2011, pp. 141–1441

Alicia Prieto-Garcia, David E. Sloane, Antonio R. Gargiulo, Anna M. Feldweg, Mariana Castells. Autoimmune progesterone dermatitis: clinical presentation and management with progesterone desensitization for successful in vitro fertilization. Fertility and Sterility_ Vol. 95, No. 3, March 1, 2011

Alexis Sidoroff, SimaHalevy, Jan Nico Bouwes Bavinck, Loı¨cVaillant, Jean-Claude Roujeau. Acute generalized exanthematous pustulosis(AGEP) –A clinical reaction pattern. J Cutan Pathol 2001:28:113–119.

Baptist AP, Baldwin JL. Autoimmune progesterone dermatitis in a patient with endometriosis: case report and review ofthe literature. Clin Mol Allergy 2004, 2: 10.

Snyder JL, Krishnaswamy G. Autoimmune progesterone dermatitis and its manifestation as anaphylaxis: a case report and literature review. Annals of Allergy, Asthma & Immunology 2003, 90: 469-476.

Wintzen M, Goor-van Egmond MBT, Noz KC. Autoimmune progesterone dermatitis presenting with purpura and petechiae. ClinExpDermatol2003, 29: 311-24.

Walling HW, Scupham RK. Autoimmune progesterone dermatitis. Case report with histologic overlap of erythema multiforme and urticarial. Int J Dermatol2008, 47: 380-82.

Rasi A, Khatami A. Autoimmune progesterone dermatitis. Int J Dermatol2004, 43: 588-90.]

Farah FS, Shbaklu Z: Autoimmune progesterone urticaria. J Allergy ClinImmunol1971, 48:257-261.

R.S. Bumbacea, I.M. Ghiordanescu, I. Tudose, L.G. Popa, C. Badiu, C. Giurcaneanu. Autoimmune progesterone dermatitis in a patient with no medical history of hormonal contraception or pregnancy. Acta Endocrinologica (Buc), vol. XI, no. 1, p. 99-102, 2015.

Schoenmakers A, Vermorken A, Degreef H, Dooms-Goossens A. Corticosteroid or steroid allergy? Contact Dermatitis 1992;26:159-62

C Dosiou, A E Hamilton, Y Pang, M T Overgaard, S Tulac, J Dong, P Thomas and L C Giudice. Expression of membrane progesterone receptors on human

T lymphocytes and Jurkat cells and activation of G-proteins by progesterone. Journal of Endocrinology 2008, 196: 67–77 .

Warin AP. Case 2, Diagnosis: erythema multiforme as a presenta¬tion of autoimmune progesterone dermatitis. Clinical and Experimental Dermatology. 26.107-108. 2001 Blackwell Science ltd.

Shelley WB, Preucel RW, Spoont SS. Autoimmune progesterone dermatitis. Cure by oophorectomy. JAMA 1964;190:35-8.

Fournier JB. Resolution of autoimmune progesterone dermatitis after treatment with oral contraceptives. JAAD Case Reports 2015;1:319-20.


  • There are currently no refbacks.

ISSN: 1560-9014