Necrolytic acral erythema without hepatitis and hypozincemia: A rare presentation.

Tasleem Arif, Dinesh Raj, Syed Suhail Amin


Necrolytic acral erythema (NAE) is a recently described entity from Egypt by El Darouti and Abu el Ela in seven patients with associated hepatitis C virus infection. It is characterized by its distinguishing psoriasiform skin lesions, an acral distribution, and histological features. The cause of the disease is not clear, though zinc deficiency, hypoaminoacidemia and hyperglucagonemia have been proposed. There are few reports in which it has occurred independently without associated HCV infection. However, NAE without associated HCV infection and normal serum zinc levels has been rarely reported till date. Herein, the authors report a rare case of NAE from India without associated HCV infection and with a normal serum zinc concentration


Hepatitis C, hypoaminoacidemia, necrolytic acral erythema, zinc deficiency

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