Psychiatric morbidity among patients with psoriasis and acne: A comparative study
Keywords:
Psychiatric morbidity, psoriasis, acneAbstract
Objective To compare occurrence of psychiatric morbidity among psoriasis and acne patients. Methods It was a cross-sectional, comparative study between 50 psoriasis and 50 acne patients in tertiary care hospital. For assessing severity of skin lesions Psoriasis Area Severity Index (PASI) and Global Acne severity (GEA) scales were applied on psoriasis and acne patients, respectively. Then General Health Questionnaire-60 (GHQ-60) was applied on both the patient groups and Mini International Neuropsychiatric Interview (MINI), Hamilton Rating Scale for Anxiety (HAM-A), Hamilton Rating Scale for Depression (HAM-D), Beck Depression Inventory (BDI) were applied on only those patients, who scored ≥12 in GHQ-60 (GHQ-60+ve). Results Psoriasis patients had significantly higher psychiatric morbidity, in terms of both GHQ-60 (p=0.00) and MINI (p=0.01). 35 (70%) and 20 (40%) patients were GHQ+ve (GHQ-60score ≥12) and psychiatric morbidity diagnosed by MINI were 22 (44%) and 10 (20%) among psoriasis and acne patients, respectively. The psychiatric diagnosis observed by MINI were: major depressive episode (18%), dysthymia (10%), generalized anxiety disorder (12%), suicidality (12%), alcohol abuse (12%), psychotic disorders (2%) among psoriasis patients and major depressive episode (6%), generalized anxiety disorder (6%), suicidality (6%), obsessive-compulsive disorder (2%), social phobia (2%), alcohol abuse (6%) among acne patients. The severity of psoriasis and acne skin lesions positively correlated with anxiety, depression in both psoriasis and acne patients. Conclusion The high psychiatric and psychosocial morbidity in psoriasis and acne patients indicates a need for regular liaison between dermatologists and psychiatrists.ÂReferences
Woodruff PWR, Higgins EM, Du Vivier AWP, Wessely S. Psychiatric illness in patients referred to a dermatology-psychiatry clinic. Gen Hosp Psychiatry. 1997;19:29-35.
Gupta MA, Gupta AK. Psychiatric and psychological co-morbidity in patients with dermatologic disorders: epidemiology and management. Am J Clin Dermatol. 2003;4:833-42
O′Sullivan RL, Lipper G, Lerner EA. The neuro-immuno-cutaneous-endocrine network: Relationship of mind and skin. Arch Dermatol. 1998;134:1431-5.
Hughes JE, Barraclough BM, Hamblin LG, White JE. Psychiatric symptoms in dermatology patients. Br J Psychiatry. 1983;143:51-4.
Gupta MA, Gupta AK. Depression and suicidal ideation in dermatology patients with acne, alopecia areata, atopic dermatitis and psoriasis. Br J Dermatol. 1998;139:846-50.
Linnet J, Jemec GB. An assessment of anxiety and dermatology life quality in patients with atopic dermatitis. Br J Dermatol. 1999;140:268-72.
Raychaudhuri SP, Farber EM. The prevalence of psoriasis in the world. J Eur Acad Dermatol Venereol. 2001;15:16-7.
Fortune DG, Richards HL, Griffiths CE. Psychologic factors in psoriasis: consequences, mechanisms, and interventions. Dermatol Clin. 2005;23:681-94.
Spencer EH, Ferdowsian HR, Barnard ND. Diet and acne: A review of the evidence. Int J Dermatol. 2009;48:339-47.
Koo J. The psychosocial impact of acne: patients' perceptions. J Am Acad Dermatol. 1995;32:S26-S30.
Fried RG, Wechsler A. Psychological problems in the acne patient. Dermatol Ther. 2006;19:237-40.
Thomas DR. Psychosocial effects of acne. J Cutan Med Surg. 2004;8(Suppl 4):3-5.
Feldman SR, Fleischer AB Jr, Reboussin DM, Rapp SR, Exum ML, Clark AR et al. The self-administered psoriasis area and severity index is valid and reliable. J Invest Dermatol. 1996;106:183-6.
Puzenat E, Bronsard V, Prey S, Gourraud PA, Aractingi S, Bagot M et al. What are the best outcome measures for assessing plaque psoriasis severity? A systematic review of the literature. J Eur Acad Dermatol Venereol. 2010;24 Suppl 2:10-6.
Fredriksson T, Pettersson U. Severe psoriasis - oral therapy with a new retinoid. Dermatologica. 1978;157:238-44.
Thiboutot DM, Weiss J, Bucko A. Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study. J Am Acad Dermatol. 2007;57:791-9.
Goldberg DP, Hillier VF. A Scaled version of the General Health Questionnaire. Psychological Med. 1979;9:139-45.
Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E et al. The Mini International Neuropsychiatric Interview. The development and validation of a structured diagnostic interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59:22-3.
Hamilton M. The Assessment of anxiety scales by rating. Br J Med Psychol. 1959;32:50-5.
Hamilton MA. Rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56-62.
Williams JB: Standardizing the Hamilton Depression Rating Scale: past, present, and future. Eur Arch Psychiatry Clin Neurosci. 2001;251 (suppl 2):II6–II12
Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561-71.
McPherson A, Martin CR. A narrative review of the Beck Depression Inventory (BDI) and implications for its use in an alcohol-dependent population. J Psychiatr Ment Health Nurs. 2010;17:19-30.
Mehta V, Malhotra SK. Psychiatric evaluation of patients with psoriasis vulgaris and chronic urticaria. Ger J Psy. 2007; 10(4):104-110.
Golchai J, Khani SH, Heiderzadeh A, Eshkevari SS, Alizade N, Eftekhari H. Comparison of anxiety and depression in patients with Acne vulgaris and healthy individuals. Indian J Dermatol. 2010;55:352-4.
Sharma N, Koranne RV, Singh RK. Psychiatric co-morbidity in Psoriasis and vitiligo: A comparative study. J Dermatol. 2001;28:419-23.
Mallon E, Newton JN, Klassen A. The quality of life in Acne: a comparison with general medical conditions using generic questionnaires. Br J Dermatol. 1999;140:672-6.
Attah Johnson FY, Mostaghimi H. Co-morbidity between dermatologic diseases and psychiatric disorders in Papua New Guinea. Int J Dermatol. 1995;34:244-8.
Pulimood S, Rajagopalan B, Rajagopalan M, Jacob M, John JK. Psychiatric morbidity among dermatology inpatients. Nat Med J India. 1996;9:208-10.
Deshpande N, Desai N, Mundra VK. Psychiatric aspects of psoriasis. Arch Indian Psychiatry. 1998;4:61-4.
Kumar S, Kachhawha D, Das Koolwal G, Gehlot S, Awasthi A. Psychiatric morbidity in psoriasis patients: A pilot study. Indian J Dermatol Venereol Leprol. 2011;77:625.
Bharath S, Shamasundar C, Raghuram R, Subbakrishna DK. Psychiatric morbidity in leprosy and psoriasis – a comparative study. Indian J Lepr. 1997;69:341-6.
Picardi A, Abeni D, Melchi CF, Puddu P, Pasquini P. Psychiatric morbidity in dermatological outpatients: an issue to be recognized. Br J Dermatol. 2000;143:983-91.
Myers JK, Weissman MM, Tischler GE, Holzer CE, Leaf PJ, Orvaschel H et al. Six-month prevalence of psychiatric disorders in three communities. Arch Gen Psychiatry. 1984;41:959-70.
Poongothai S, Pradeepa R, Ganesan A, Mohan V. Prevalence of depression in a large urban South Indian population—the Chennai Urban Rural Epidemiology Study (CURES-70). PLoS One. 2009;4:e7185.
Mattoo SK, Handa S, Kaur I, Gupta N, Malhotra R. Psychiatric morbidity in psoriasis, prevalence and correlates in India. Ger J Psychiatry. 2005;8:17-22.
Kumar V, Mattoo SK, Handa S. Psychiatric morbidity in pemphigus and psoriasis: A comparative study from India. Asian J Psychiatr. 2013;6:151-6.
Kumar LV. Suicide and its prevention: The urgent need in India. Indian J Psychiatry. 2007;49:81-4.
Callahan CM, Hendrie HC, Nienaber NA. Suicidal ideation among older primary care patients. J Am Geriatrics Soc. 1996;44:1205-9.
Kishi Y, Robinson RG, Kosier JT. Suicidal ideation among patients with acute life-threatening physical illness: patients with stroke, traumatic brain injury, myocardial infarction, and spinal cord injury. Psychosomatics. 2001;42:382-90.
Yazici K, Baz K, Yazici AE, Köktürk A, Tot S, Demirseren D et al. Disease-specific quality of life is associated with anxiety and depression in patients with acne. J Eur Acad Dermatol Venereol. 2004;18:435-9.
Mazzotti E, Mastroeni S, Lindau J, Lombardo G, Farina B, Pasquini P. Psychological distress and coping strategies in patients attending a dermatology outpatient clinic. J Eur Acad Dermatol Venereol. 2012;26:746-54.
Agrawal JP, Dubey AK, Sharma DK. Study of prevalence of psychiatric morbidity, especially depressive & anxiety disorders in acne vulgaris patients in Hadoti region. J Evol Med Dent Sci. 2014;3:3689-94.
Magin P, Adams J, Heading G, Pond D, Smith W. Experiences of appearance-related teasing and bullying in skin diseases and their psychological sequelae: results of a qualitative study. Scand J Caring Sci. 2008;22:430-6.
Behnam B, Taheri R, Ghorbani R, Allameh P. Psychological impairments in the patients with acne. Indian J Dermatol. 2013;58:26-9.
Ozturk A, Deveci E, BaÄŸcioÄŸlu E, Atalay F, Serdar Z. Anxiety, depression, social phobia, and quality of life in Turkish patients with acne and their relationships with the severity of acne. Turk J Med Sci. 2013;43:660-6.
Mulder MMS, Sigurdsson V, van Zuuren EJ, Klaassen EJ, Faber JA, de Wit JB et al. Psychosocial impact of Acne vulgaris: evaluation of the relation between a change in clinical acne severity and psychosocial state. Dermatology. 2001;203:124-30.
Layton AM. Disorders of the sebaceous glands. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook's Textbook of Dermatology. Oxford: Wiley-Blackwell; 2010. P. 42.1-42.89.
Dalgard F, Gieler U, Holm JØ, Bjertness E, Hauser S. Self-esteem and body satisfaction among late adolescents with acne: results from a population survey. J Am Acad Dermatol. 2008;59:746-51.
Uhlenhake E, Yentzer BA, Feldman SR. Acne vulgaris and depression: a retrospective examination. J Cosmet Dermatol. 2010;9:59-63.
Shahzad N, Nasir J, Ikram U, Asmaa-ul-Haque UA, Qadir A, Sohail MA. Frequency and psychosocial impact of acne on university and college students. J Coll Physicians Surg Pak. 2011;21:442-3.
Sarkar S, Sarkar A, Saha R, Sarkar T. Psoriasis and psychiatric morbidity: a profile from a tertiary care centre of Eastern India. J Family Med Prim Care. 2014;3:29-32.
Fortune DG, Main CJ, O'Sullivan TM, Griffith CEM. Quality of life in patients with psoriasis: the contribution of clinical variables and psoriasis specific stress. Br J Dermatol. 1997;137:755-60.
Vardy D, Besser A, Amir M. Experiences of stigmatization play a role in mediating the impact of disease severity on quality of life in psoriasis patients. Br J Dermatol. 2002;147:736-42.
Lu Y, Duller P, Van Der Valk PGM, Evers AWM. Helplessness as predictor of perceived stigmatization in patients with psoriasis and atopic dermatitis. Dermatol Psychosom. 2003;14:146-50.
Richards HL, Fortune DG, Griffiths CE, Main CJ. The contribution of perceptions of stigmatisation to disability in patients with psoriasis. J Psychosom Res. 2001;50:11-5.
Kimball AB, Jacobson C, Weiss S, Vreeland MG, Wu Y. The psychosocial burden of psoriasis. Am J Clin Dermatol. 2005;6:383-92.
Meyer N, Paul C, Feneron D, Bardoulat I, Thiriet C, Camara C et al. Psoriasis: an epidemiological evaluation of disease burden in 590 patients. J Eur Acad Dermatol Venereol. 2010;24:1075-82.
Rapp SR, Feldman SR, Exum ML, Fleischer AB, Reboussin DM. Psoriasis causes as much disability as other major medical diseases. J Am Acad Dermatol. 1999;41:401-7.
Scharloo M, Kaptein AA, Weinman, J. Patients’ illness perceptions and coping as predictors of functional status in psoriasis: A 1-year follow-up. Br J Dermatol. 2002;142:899-907.
Fortune DG, Richards HL, Griffiths CEM, Main CJ. Psychological stress, distress and disability in patients with psoriasis: Consensus and variation in the contribution of illness perceptions, coping and alexithymia. Br J Clin Psychol. 2002;41:157-74.
Gupta MA, Gupta AK. Psoriasis and sex: a study of moderately to severely affected patients. Int J Dermatol. 1997;36:259-62.
Madhulika AG, Nicholas JS, Aditya KG. Suicidal ideation in psoriasis. Int J Dermatol. 1993;32:188-90.
Grahame V, Dick DC, Morton CM. The psychological correlates of treatment efficacy in acne. Dermatol Psychosom. 2002;3:119-25.
Arnold L. Dermatology. In: Levenson JL, ed. Essentials of Psychosomatic Medicine. Arlington, VA: American Psychiatric Publishing; 2007. P. 217-39.