Clinical versus patho-microbial diagnosis of leprosy: a comparative study in North Bengal population of India

Anushweta Singh, Rajesh Kumar Mandal, Sabyasachi Banerjee, Biswajit Halder, Manas Pratim Roy


Objective To correlate and compare clinical diagnosis with histopathological findings and acid-fast bacilli status in different types of leprosy to compare the efficacy of bacillary index in slit-skin smears and bacterial index of granuloma in biopsies for detecting the acid fast bacilli.


Methods Detailed history was taken and thorough clinical examination was done. The findings were noted in a predesigned standard format. Slit-skin smear and skin biopsy were performed and evaluated. Subsequently, association was tested between the histopathological findings, bacteriological index and clinical classification.


Results Among the 72 study cases, diagnosis of leprosy was corroborated with histopathological and microbiological finding in 78% cases, among which LL (27.8%) constituted the major group, followed by TT (18.1%), BL (15.3%), BT (12.5%) with the least being BB (4.2%). Another 22.2% cases were non-leprosy histopathologically and diagnosed as nonspecific dermatitis (NSD).


Conclusion Histopathological examination along with bacteriological index of skin biopsy should be carried out in all cases of leprosy to arrive at a definite diagnosis of leprosy and to classify the type of the disease.



Leprosy; Histopathology; Slit skin smear

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